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  2. LPL Receptor
  3. SLF1081851

SLF1081851 

Cat. No.: HY-149004
Handling Instructions

SLF1081851 (16 d) is an effective Sphingolipid Transporter 2 (Spns2) (S1P transporter) inhibitor with an IC50 value of 1.93 μM (S1P), SLF1081851 inhibits SphK2 with an IC50 value of ≈ 30 μM (SphK2), and is at least 15-fold more selective for SphK2 than SphK1. SLF1081851 has the potential to investigate Spns2 biology and can be used for autoimmune encephalomyelitis (EAE) research.

For research use only. We do not sell to patients.

SLF1081851 Chemical Structure

SLF1081851 Chemical Structure

CAS No. : 2763730-97-6

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Description

SLF1081851 (16 d) is an effective Sphingolipid Transporter 2 (Spns2) (S1P transporter) inhibitor with an IC50 value of 1.93 μM (S1P), SLF1081851 inhibits SphK2 with an IC50 value of ≈ 30 μM (SphK2), and is at least 15-fold more selective for SphK2 than SphK1. SLF1081851 has the potential to investigate Spns2 biology and can be used for autoimmune encephalomyelitis (EAE) research[1].

IC50 & Target

IC50: 1.93 μM (SIP), ≈ 30 μM (SphK2)[1].

In Vivo

SLF1081851 (C57BL/6j strain mice or Sprague-Dawley strain rats; 10 or20 mg/kg; i.p., 4 h postdose) significantly inhibits circulating lymphocytes and plasma S1P, recapitulates the genetic phenotype of Spns2 null mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (C57BL/6j strain), rats (Sprague-Dawley strain)[1].
Dosage: 10, 20 mg/kg.
Administration: I.p., blood was drawn 4 h postdose.
Result: Inhibited circulating lymphocytes and plasma S1P [1].
Animal Model: 4 week old male rats[1].
Dosage: 10 mg/kg.
Administration: I.p. (Pharmacokinetic Analysis).
Result: Reached a maximum concentration of 5 μM in blood at 2 h with drug levels sustained at ≥ 2 μM for at least 24 h, proved a half-life of over 8 h in rats. The appearance of SPNS2-IN-1 in circulation correlated with a maximal decrease in lymphocyte count at 4 h (25% lower compared to time = 0).
Molecular Weight

343.51

Formula

C21H33N3O

CAS No.
SMILES

NCCCC1=NC(C2=CC=C(CCCCCCCCCC)C=C2)=NO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
SLF1081851
Cat. No.:
HY-149004
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