SLF1081851 TFA
Based on 4 publication(s) in Google Scholar
SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2763730-98-7
- Formule: C23H34F3N3O3
- Masse moléculaire:457.53
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SLF1081851 TFA
More
Activité biologique
Spns2 (spinster homologue 2)[1]
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule, and Spns2 exerts the functions to maintain lymph S1P[1].
SLF1081851 (TFA) (compound 16d) (0-5 μM; 18-20 h) inhibits S1P release with an IC50 value of 1.93 μM in Hela cells[1].
SLF1081851 (TFA) (0-30 μM; 20 min) inhibits mSphK1 (recombinant mouse SphK) (10 μM) and mSphK2 (5 μM) in a dose-dependent manner and suggests at least 15-fold selectivity (SphK1 IC50≥30 μM; SphK2 IC50≈30 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice[1]
-
Dosage:20 mg/kg
-
Administration:Intraperitoneal injection; blood was drawn 4 h postdose
-
Result:Significantly decreased circulating lymphocyte count and plasma S1P concentration.
-
Animal Model:SpragueDawley mice (4-week-old)[1]
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal injection; single dose; measured at 0, 0.5, 1, 2, 4, 6, and 24 h postdose
-
Result:Reached a maximum concentration of 5 μM in blood at 2 h with drug levels sustained at ≥ 2 μM for at least 24 h, proved a half-life of over 8 h in rats. The appearance of SPNS2-IN-1 in circulation correlated with a maximal decrease in lymphocyte count at 4 h (25% lower compared to time =0).
Chemical Information
-
CAS No. 2763730-98-7
-
Masse moléculaire 457.53
-
Formule C23H34F3N3O3
-
SMILES
NCCCC1=NC(C2=CC=C(CCCCCCCCCC)C=C2)=NO1.O=C(O)C(F)(F)F
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Cell
Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. [Abstract]2023 Jun 8;186(12):2644-2655.e16. PMID: 37224812 -
Cell Commun Signal
Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE2 production. [Abstract]2024 Sep 30;22(1):463. PMID: 39350143 -
Int Immunopharmacol
Liquiritigenin attenuates alcohol-induced liver inflammation by regulating the SphK1/S1P/SPNS2 signaling pathway. [Abstract]2026 Jan 1;168(Pt 2):115881. PMID: 41297343 -
Pflugers Arch
2025 Jun;477(6):815-826. PMID: 39899071
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLF1081851 TFA Related Classifications
HY-149004A Related Classifications
Powered by Bioz