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Cat. No.: HY-149004B

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SLF1081851 hydrochloride

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system.

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CAS No.: 2999629-35-3
Formule: C₂₁H₃₄ClN₃O
Masse moléculaire:379.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

SLF1081851 hydrochloride Chemical Structure

CAS No.: 2999629-35-3

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Description

SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system^[1].

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Chemical Information

CAS No. 2999629-35-3
Masse moléculaire 379.97
Formule C₂₁H₃₄ClN₃O
SMILES

NCCCC1=NC(C2=CC=C(CCCCCCCCCC)C=C2)=NO1.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Cell

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. [Abstract]

2023 Jun 8;186(12):2644-2655.e16. PMID: 37224812
Cell Commun Signal

Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE2 production. [Abstract]

2024 Sep 30;22(1):463. PMID: 39350143
Int Immunopharmacol

Liquiritigenin attenuates alcohol-induced liver inflammation by regulating the SphK1/S1P/SPNS2 signaling pathway. [Abstract]

2026 Jan 1;168(Pt 2):115881. PMID: 41297343
Pflugers Arch

Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification. [Abstract]

2025 Jun;477(6):815-826. PMID: 39899071

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Russell Fritzemeier, et al. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2022, 65, 11. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SLF1081851 hydrochloride

4 Cited Publications

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SLF1081851 hydrochloride

Publications Citing Use of MedChemExpress (MCE) SLF1081851 hydrochloride

Voir tous les produits spécifiques à Isoform LPL Receptor

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Chemical Information

Publications (4)

Pureté et documentation

Références

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SLF1081851 hydrochloride Related Classifications

HY-149004B Related Classifications