2. GPCR/G Protein
  3. LPL Receptor
  4. SLB1122168

SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats.

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SLB1122168

SLB1122168 Chemical Structure

CAS No. : 2999629-17-1

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SLB1122168 Related Antibodies

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Description

SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats[1].

IC50 & Target[1]

S1P

 

In Vitro

SLB1122168 (Compound 33p) (0.3 μM; 18-20 h) potently inhibits Spns2-mediated S1P release in mouse Spns2-transfected HeLa cells with an IC50 of 94 nM[1].
SLB1122168 (10 μM) shows no inhibitory activity against Mfsd2b-mediated S1P release from mouse red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLB1122168 Related Antibodies
In Vivo

SLB1122168 (Compound 33p) (10-30 mg/kg; i.p.; single dose) induces a significant, dose-dependent decrease in circulating lymphocytes without altering plasma S1P levels in female C57BL/6J mice[1].
SLB1122168 (10 mg/kg; i.p.; single dose) induces a 55% decrease in circulating lymphocytes in male Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (female)[1]
Dosage: 10 mg/kg; 30 mg/kg
Administration: i.p.; single dose
Result: Induced a significant decrease in circulating lymphocytes relative to vehicle control at 4 h post-dose.
Caused no significant change in plasma S1P levels at 4 h post-dose.
Induced a dose-dependent decrease in circulating lymphocytes relative to vehicle control at 16 h post-dose.
Molecular Weight

393.99

Formula

C22H36ClN3O
CAS No.
SMILES

CCCCCCCCCCC1=CC=C2C(OC(NC[C@@H]3CNCC3)=N2)=C1.Cl
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Purity & Documentation
References
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SLB1122168 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLB11221682999629-17-1SLB 1122168SLB-1122168LPL ReceptorLysophospholipid ReceptorSpns2-mediated S1P releasecirculating lymphocytesInhibitorinhibitorinhibit

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