SLB1122168 free base
Based on 1 publication(s) in Google Scholar
SLB1122168 free base is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 free base inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 free base induces lymphopenia in circulating lymphocytes in mice and rats.
For research use only. We do not sell to patients.
- CAS No.: 2764877-95-2
- Formula: C22H35N3O
- Molecular Weight:357.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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S1P |
SLB1122168 free base (Compound 33p) (0.3 μM; 18-20 h) potently inhibits Spns2-mediated S1P release in mouse Spns2-transfected HeLa cells with an IC50 of 94 nM[1].
SLB1122168 free base (10 μM) shows no inhibitory activity against Mfsd2b-mediated S1P release from mouse red blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SLB1122168 free base (10 mg/kg; i.p.; single dose) induces a 55% decrease in circulating lymphocytes in male Sprague-Dawley rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (female)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:i.p.; single dose
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Result:Induced a significant decrease in circulating lymphocytes relative to vehicle control at 4 h post-dose.
Caused no significant change in plasma S1P levels at 4 h post-dose.
Induced a dose-dependent decrease in circulating lymphocytes relative to vehicle control at 16 h post-dose.
Chemical Information
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CAS No. 2764877-95-2
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Molecular Weight 357.53
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Formula C22H35N3O
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SMILES
CCCCCCCCCCC1=CC=C2OC(NC[C@H]3CCNC3)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion. [Abstract]2026 Jan 28;22(1):e1013886. PMID: 41604433
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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