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Cat. No.: HY-50692

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CAY10734

CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC₅₀ of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant.

For research use only. We do not sell to patients.

CAS No.: 635701-59-6
Formula: C₂₃H₂₅N₃O₃
Molecular Weight:391.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CAY10734 Chemical Structure

CAS No.: 635701-59-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All LPL Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.6 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	1 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	70 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10000 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	12 μM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10 μM Compound: 5	Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: 5	Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	1 nM Compound: 5	Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	70 nM Compound: 5	Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	12 μM Compound: 5	Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: C	Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes	[PMID: 24900286]
CHO	IC₅₀	12 nM Compound: C	Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes	[PMID: 24900286]

Chemical Information

CAS No. 635701-59-6
Molecular Weight 391.46
Formula C₂₃H₂₅N₃O₃
SMILES

O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=CC=C(CC(C)C)C=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Z, et al., Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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CAY10734

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CAY10734 Related Classifications

HY-50692 Related Classifications