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Art. -Nr.: HY-50692

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CAY10734

Name: CAY10734
Brand: MedChemExpress
SKU: HY-50692
Price: 122.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC₅₀ of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant.

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CAS. Nr.: 635701-59-6
Formel: C₂₃H₂₅N₃O₃
Molecular Weight:391.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CAY10734 Chemical Structure

CAS. Nr.: 635701-59-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- Cellular Effect
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Biologische Aktivität

Beschreibung

Alle LPL Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.6 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	1 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	70 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10000 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	12 μM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10 μM Compound: 5	Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: 5	Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	1 nM Compound: 5	Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	70 nM Compound: 5	Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	12 μM Compound: 5	Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: C	Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes	[PMID: 24900286]
CHO	IC₅₀	12 nM Compound: C	Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes	[PMID: 24900286]

Chemical Information

CAS. Nr. 635701-59-6
Molecular Weight 391.46
Formel C₂₃H₂₅N₃O₃
SMILES

O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=CC=C(CC(C)C)C=C4)=N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Z, et al., Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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CAY10734

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S1PR1 modulator 1

NIBR0213

W146 TFA

1-Monopalmitolein

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CYM5442 (Standard)

Alle LPL Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

CAY10734

2-Acetyl-4-tetrahydroxybutyl imidazole

Methotrexate hydrate

EGTA

CYM5442

P053

S1PR1 modulator 1

NIBR0213

W146 TFA

1-Monopalmitolein

A6770

ABC34

CYM5442 (Standard)

Alle LPL Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CAY10734 Related Classifications

HY-50692 Related Classifications

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