2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3564-8. doi: 10.1016/j.bmcl.2006.03.090.
Lin Yan  1 ,  Richard Budhu ,  Pei Huo ,  Christopher L Lynch ,  Jeffrey J Hale ,  Sander G Mills ,  Richard Hajdu ,  Carol A Keohane ,  Mark J Rosenbach ,  James A Milligan ,  Gan-Ju Shei ,  Gary Chrebet ,  James Bergstrom ,  Deborah Card ,  Suzanne M Mandala
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. [email protected]
PMID: 16621543 DOI: 10.1016/j.bmcl.2006.03.090
Abstract

A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.