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Cat. No.: HY-110314

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CYM50358 hydrochloride

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection.

For research use only. We do not sell to patients.

CAS No.: 1781750-72-8
Formula: C₂₀H₁₉Cl₃N₂O₂
Molecular Weight:425.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CYM50358 hydrochloride Chemical Structure

CAS No.: 1781750-72-8

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Description

CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection^[1].

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Chemical Information

CAS No. 1781750-72-8
Molecular Weight 425.74
Formula C₂₀H₁₉Cl₃N₂O₂
SMILES

O=C(C1=CC=C(O1)C2=C(C=CC(Cl)=C2)Cl)NC3=C(C=C(C=C3C)CN)C.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Cancer Commun (Lond)

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis. [Abstract]

2025 Jul 16. PMID: 40665874
Biomed Pharmacother

Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4. [Abstract]

2023 Oct:166:115400. PMID: 37657263
Environ Pollut

Polycyclic aromatic hydrocarbon aggravates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease through disturbing hepatocyte sphingolipid metabolism. [Abstract]

2025 Jul 16:383:126846. PMID: 40681076

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guerrero M, et al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CYM50358 hydrochloride

3 Cited Publications

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CYM50358 hydrochloride

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CYM50358 hydrochloride

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

CYM50358 hydrochloride

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CYM50358 hydrochloride

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

CYM50358 hydrochloride Related Classifications

HY-110314 Related Classifications