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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
extrinsic apoptosis
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "extrinsic apoptosis" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-N0213
CAS No.: 18059-10-4
Synonyms: Verticinone; Raddeanine
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2 Cited Publications
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VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways .
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2 Cited Publications
Cat. No.: HY-N7043
CAS No.: 142796-21-2
Synonyms: Erinacine A
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PP5-IN-1 is a competitive and selective serine/threonine protein phosphatase 5 (PP5) inhibitor with a Ki value of 244 nM. PP5-IN-1 induces extrinsic apoptosis (Apoptosis), disrupts the integrity of complex II, and activates Caspase 8. PP5-IN-1 can be used in research related to clear cell renal cell carcinoma .
Cat. No.: HY-N2281
CAS No.: 97938-31-3
Category:
Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N7071
CAS No.: 79356-08-4
Synonyms: Maduramycin
Target:
Cat. No.: HY-179124
Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS). Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR)-dependent and -independent prostate cancers and leukemia .
Cat. No.: HY-178099
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Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer .
Cat. No.: HY-P10833
Cat. No.: HY-161098
CAS No.: 2750370-67-1
Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC50 values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively .
Cat. No.: HY-P990901
CAS No.: 2796349-94-3
Synonyms: IGM-8444
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Cat. No.: HY-N10018
CAS No.: 154822-57-8
Synonyms: 25-Anhydrocimigenol xyloside
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Cat. No.: HY-164489
CAS No.: 1260401-93-1
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative .
Cat. No.: HY-N7071AR
CAS No.: 84878-61-5
Synonyms: Maduramycin ammonium (Standard)
Category:
Cat. No.: HY-N0213R
CAS No.: 18059-10-4
Synonyms: Verticinone (Standard); Raddeanine (Standard)
Cat. No.: HY-N7043R
CAS No.: 142796-21-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
