(+)-Erinacin A
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(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage.
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- Pureté: 99.81%
- CAS No.: 156101-08-5
- Formule: C25H36O6
- Masse moléculaire:432.55
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
(+)-Erinacin A (30 μM; 3-24 h) activates the extrinsic and intrinsic apoptosis pathways in DLD-1 cells and reduces the expression of anti-apoptotic proteins[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DLD-1 Cells
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Concentration:30 µM
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Incubation Time:3-24 h
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Result:Increased active forms of caspase-3, caspase-9 and caspase-8. Decreased the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL. Upregulated the levels of phosphorylated JNK Thr183 and Tyr185, NFκB, and p300 proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DLD-1 xenograft mouse model[5].
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Dosage:1, 2 and 5 mg/kg
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Administration:Intraperitoneal injection (i.p.) once a day for 5 days
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Result:Inhibited tumor volume by 60%, 32% and 26%.
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Animal Model:SAM rats with transient stroke[4].
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Dosage:1, 5 and 10 mg/kg
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Administration:Intraperitoneal injection (i.p.) single dose
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Result:Induced NeuN immune response in the entire brain region of SAM rats, and increased the number of NeuN cells. Inhibited the activation of iNOS and p38/MAPK pathways and the expression of CHOP and nitrotyrosine proteins in rat brain tissue.
Chemical Information
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CAS No. 156101-08-5
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Appearance Solid
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Masse moléculaire 432.55
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Formule C25H36O6
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Color Light yellow to yellow
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SMILES
O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@](CC[C@]3(C)C4=C(C(C)C)CC3)(C)C4=CC=C(C=O)C2)OC1
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Synonyms
Erinacine A
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Structure Classification
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Initial Source
Hericium erinaceus
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
Ethanol : 10 mg/mL (23.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Bailly C, et.al. Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res. 2020 Sep;159:104953. [Content Brief]
[2]. Tsai-Teng T, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice[J]. Journal of biomedical science, 2016, 23: 1-12. [Content Brief]
[3]. Prasher P, et al. Key oncologic pathways inhibited by Erinacine A: a perspective for its development as an anticancer molecule[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114332. [Content Brief]
[4]. Lee K F, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine[J]. International journal of molecular sciences, 2014, 15(9): 15073-15089. [Content Brief]
[5]. Lee K C, et al. Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, Fas, and Fas ligand via the JNK/p300/p50 signaling pathway with histone acetylation[J]. Frontiers in Pharmacology, 2019, 10: 1174. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3119 mL | 11.5594 mL | 23.1187 mL | 57.7968 mL |
| 5 mM | 0.4624 mL | 2.3119 mL | 4.6237 mL | 11.5594 mL | |
| 10 mM | 0.2312 mL | 1.1559 mL | 2.3119 mL | 5.7797 mL | |
| 15 mM | 0.1541 mL | 0.7706 mL | 1.5412 mL | 3.8531 mL | |
| 20 mM | 0.1156 mL | 0.5780 mL | 1.1559 mL | 2.8898 mL |
(+)-Erinacin A Related Classifications
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