156101-08-5
Chemical Structure
(+)-Erinacin A
Synonym(s): Erinacine A
- CAS No.: 156101-08-5
- Formula:C25H36O6
- Molecular Weight:432.55
IUPAC Name: (3aR,5aR,6S)-1-isopropyl-3a,5a-dimethyl-6-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2,3,3a,4,5,5a,6,7-octahydrocyclohepta[e]indene-8-carbaldehyde
InChIKey: LPPCHLAEVDUIIW-NLLUTMDRSA-N
SMILES: O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@](CC[C@]3(C)C4=C(C(C)C)CC3)(C)C4=CC=C(C=O)C2)OC1
Biological Activity: (+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage[1][2][3][4][5].
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(+)-Erinacin A | 99.81% | (+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage. | ||||||||||||||||||||
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References
- [1]. Bailly C, et.al. Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res. 2020 Sep;159:104953. [Content Brief]
- [2]. Tsai-Teng T, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice[J]. Journal of biomedical science, 2016, 23: 1-12. [Content Brief]
- [3]. Prasher P, et al. Key oncologic pathways inhibited by Erinacine A: a perspective for its development as an anticancer molecule[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114332. [Content Brief]
- [4]. Lee K F, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine[J]. International journal of molecular sciences, 2014, 15(9): 15073-15089. [Content Brief]
- [5]. Lee K C, et al. Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, Fas, and Fas ligand via the JNK/p300/p50 signaling pathway with histone acetylation[J]. Frontiers in Pharmacology, 2019, 10: 1174. [Content Brief]
