2. Apoptosis
  3. Caspase
  4. Cimiside E

Cimiside E  (Synonyms: 25-Anhydrocimigenol xyloside)

Cat. No.: HY-N10018
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Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways.

For research use only. We do not sell to patients.

Cimiside E Chemical Structure

Cimiside E Chemical Structure

CAS No. : 154822-57-8

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Cimiside E Related Antibodies

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Description

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2].

IC50 & Target[1]

Caspase 3

 

In Vitro

Cimiside E (30-90 μM; 24 h) arrest cell cycle and induces apoptosis in ASG cells[1].
Cimiside E (30-90 μM; 12-48 h) has a strong cytotoxicity on AGS cells and shows anti-proliferative activity[1].
Cimiside E (15-60 μM; 6-24 h) induces DNA fragment, (30-60; 1-6 h) activates expression of FasL at 3 h and Fas from 1 h in ASG cells[1].
Cimiside E (30-90 μM; 3-24 h) mediates caspase cascade, by increasing Bax/Bcl-2 ratio and decreasing mutant type (mt) p53 and procaspase 3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cimiside E Related Antibodies

Western Blot Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, 12 h, and 24 h
Result: Increased the ratio of Bax/Bcl-2 expression from 60 μM.
Decreased mutant type (mt) p53 levle from 12 h at 30 µM.
Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM.

Cell Proliferation Assay[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 12 h, 24 h, and 48 h
Result: Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment.

Cell Cycle Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, and 24 h
Result: Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM).
Molecular Weight

602.80

Formula

C35H54O8
CAS No.
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]5([H])[C@@]6(O[C@]([C@@H](O6)C(C)=C)([H])C[C@H]5C)[C@@H]2O)C)[C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)([H])CC3)C4
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Cimiside E Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Cimiside E154822-57-825-Anhydrocimigenol xylosideCaspaseInhibitorinhibitorinhibit

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