Cimicifuga racemosa (L.) Nutt.

Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS.

26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels.

Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca²⁺ channels (ROC) inhibitor, suppressing extracellular Ca²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca²⁺ channels.

Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca²⁺ influx through receptor-operated Ca²⁺ channels (ROC) in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca²⁺ channels (VDC) or K⁺-induced contractions.

Cimicifugic acid E (2-E-Feruloylpiscidic acid) is a ferulic acid ester compound found in the rhizomes of Cimicifuga racemosa. Cimicifugic acid E is promising for research of menopausal syndrome.

25-Anhydrocimigenol-3-O-β-D-xylopyranoside is a compound that can be isolated from the roots or rhizomes of Cimicifuga racemosa.

23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa.

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC₅₀ value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways.

25-O-Methylcimigenol-3-O-D-xylopyranoside is an active compound. 25-O-Methylcimigenol-3-O-D-xylopyranoside can be used for the research of various biochemical .

Cimifugin (Standard) is the analytical standard of Cimifugin. This product is intended for research and analytical applications. Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS.

26-Deoxyactein (Standard) is the analytical standard of 26-Deoxyactein. This product is intended for research and analytical applications. 26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels.

Cimicifugic acid B is an antioxidant with an IC₅₀ of 21 µM in the DPPH assay.

Cimicifugic acid F is a hydroxycinnamic acid ester of piscidic acid isolated from the rhizomes of Cimicifuga racemosa.