50982-40-6
50982-40-6
Chemical Structure
Fukinolic acid
- CAS No.: 50982-40-6
- Formula:C20H18O11
- Molecular Weight:434.35
SMILES: OC(C=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O)=C(C=C1)O
Biological Activity: Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels[1][2].
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Fukinolic acid | Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels. | |||||||||||||||||||||
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References
- [1]. Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998;21(11):1163-1168 [Content Brief]
- [2]. Ma Y, et al. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. Int J Antimicrob Agents. 2019;53(2):128-136. [Content Brief]
