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Cat. No.: HY-N15737

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Fukinolic acid

Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca²⁺ channels (ROC) inhibitor, suppressing extracellular Ca²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca²⁺ channels.

For research use only. We do not sell to patients.

CAS No.: 50982-40-6
Formula: C₂₀H₁₈O₁₁
Molecular Weight:434.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Fukinolic acid Chemical Structure

CAS No.: 50982-40-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

In Vitro

Fukinolic acid (300 μM; 1 h; rat aortic strips) induces relaxation of Norepinephrine-precontracted rat aortic strips with endothelium independence and suppresses Ca²⁺-induced contraction in Norepinephrine-preincubated rat aortic strips via extracellular Ca²⁺ influx inhibition^[1].
Fukinolic acid (4.3 µg/mL; 4 days) reduces EV71 BrCr virus-induced cytopathic effect by 50% and causes 50% cytotoxicity at 500 µg/mL^[2].
Fukinolic acid (0-230 µM; 16 h; COS-1) does not inhibit EV-A71 3C protease activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 50982-40-6
Molecular Weight 434.35
Formula C₂₀H₁₈O₁₁
SMILES

OC(C=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O)=C(C=C1)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998;21(11):1163-1168 [Content Brief]

[2]. Ma Y, et al. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. Int J Antimicrob Agents. 2019;53(2):128-136. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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