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Cat. No.: HY-N15735

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Cimicifugic acid D

(Synonyms: 2-Caffeoylpiscidic acid)

Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca²⁺ influx through receptor-operated Ca²⁺ channels (ROC) in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca²⁺ channels (VDC) or K⁺-induced contractions.

For research use only. We do not sell to patients.

CAS No.: 219986-51-3
Formula: C₂₀H₁₈O₁₀
Molecular Weight:418.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Cimicifugic acid D Chemical Structure

CAS No.: 219986-51-3

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Biological Activity
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Biological Activity

Description

All Calcium Channel Isoforms :

In Vitro

Cimicifugic acid D (300 μM; 1 h; rat aortic strips) causes relaxation of Norepinephrine-precontracted aortic strips, and reduces Norepinephrine-induced concentration-dependent contraction^[1].
Cimicifugic acid D (30 μM; 1 h; rat aortic strips) inhibits Ca²⁺-induced contraction in Norepinephrine-pretreated aortic strips^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 219986-51-3
Molecular Weight 418.35
Formula C₂₀H₁₈O₁₀
SMILES

OC(C=C1)=CC=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O
Synonyms

2-Caffeoylpiscidic acid
Structure Classification
- Phenols
- Polyphenols
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998 Nov;21(11):1163-8. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cimicifugic acid D

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cimicifugic acid D Related Classifications

HY-N15735 Related Classifications