1. Apoptosis
  2. Apoptosis
  3. Isosilybin A

Isosilybin A 

Cat. No.: HY-N7043 Purity: >99.0%
Handling Instructions

Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis.

For research use only. We do not sell to patients.

Isosilybin A Chemical Structure

Isosilybin A Chemical Structure

CAS No. : 142796-21-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 265 Get quote
1 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].

Molecular Weight

482.44

Formula

C₂₅H₂₂O₁₀

CAS No.

142796-21-2

SMILES

O=C1[[email protected]](O)[[email protected]@H](C2=CC=C(O[[email protected]](C3=CC=C(O)C(OC)=C3)[[email protected]@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0728 mL 10.3640 mL 20.7280 mL
5 mM 0.4146 mL 2.0728 mL 4.1456 mL
10 mM 0.2073 mL 1.0364 mL 2.0728 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Isosilybin AApoptosisInhibitorinhibitorinhibit

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Product Name:
Isosilybin A
Cat. No.:
HY-N7043
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