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lept

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (1) Chloride Channel (1) Cholinesterase (ChE) (1) CRM1 (3) Drug Derivative (2) Fungal (1) GABA Receptor (1) HIV (1) HPPD (1) iGluR (2) Insecticide (1) Monoamine Oxidase (1) Parasite (1) Proteasome (1)
By Research Areas:	Cancer (8) Infection (5) Metabolic Disease (2) Neurological Disease (4)

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16909

Leptomycin B 20+ Cited Publications CI 940; LMB	CRM1 Fungal Antibiotic	Infection Cancer
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .

HY-114991

Leptospermone	HPPD	Others
Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC₅₀ of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect .

HY-125515

Tetrahydroharmine leptaflorine	Monoamine Oxidase	Neurological Disease
Tetrahydroharmine (Leptaflorine) is a selective reversible monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 74 nM. Tetrahydroharmine can be used for the research of parkinson’s disease .

HY-P1523

Leptin (22-56), human	iGluR	Metabolic Disease
Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).

HY-N6795

Leptomycin A	CRM1 HIV Antibiotic	Infection
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-164710

Biotinylated leptomycin B b-LMB	CRM1	Others
Biotinylated leptomycin B is a compound used to quantify nuclear export protein 1 (XPO1) occupancy and is used to study the interaction of SINE compounds with XPO1 and the response of cancer cells to related compounds.

HY-N4206

Leptomerine	Cholinesterase (ChE)	Neurological Disease
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-N16497

Leptosperin	Bacterial	Infection
Leptosperin is a glycoside of methyl syringate found in manuka honey derived from the Leptospermum species Leptospermum scoparium. Leptosperin exhibits antibacterial activity. Leptosperin can be used for the research of infection .

HY-N10332

Leptosphaerodione	Proteasome	Cancer
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC₅₀ value of 3.2 μM. Anti-tumor agent .

HY-135137

Leptosin I	Others	Cancer
Leptosin I is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin I inhibits Leukemia lymphocyte P388 in culture with an ED₅₀ of 1.13 μg/mL .

HY-P3340

Leptin (116-130)	iGluR	Neurological Disease
Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) .

HY-N16999

Leptabiside C	Drug Derivative	Others
Leptabiside C is a natural phenolic compound.

HY-N13816

Leptabiside A	Drug Derivative	Others
Leptabiside A is a natural phenolic compound.

HY-N14384

Leptofuranin D	Others	Cancer
Leptofuranin D is found in the strain of Str. tanashiensis. Leptofuranin D causes the stagnation of normal cells, but it can cause the death of transformed cells .

HY-N14381

Leptofuranin A	Others	Cancer
Leptofuranin A is found in the strain of Str. tanashiensis. Leptofuranin A causes the stagnation of normal cells, but it can cause the death of transformed cells .

HY-N14383

Leptofuranin C	Others	Cancer
Leptofuranin C is found in the strain of Str. tanashiensis. Leptofuranin C causes the stagnation of normal cells, but it can cause the death of transformed cells .

HY-130468

Leptosin J	Others	Cancer
Leptosin J is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin J inhibits Leukemia lymphocyte P388 in culture with an ED₅₀ of 1.25 μg/mL .

HY-N18113

Leptodactylone	Others	Others
Leptodactylone is a compound isolated from the stem bark of Citrus medica L. var. sarcodactylis SWINGLE .

HY-N14382

Leptofuranin B	Others	Cancer
Leptofuranin B is found in the strain of Str. tanashiensis. Leptofuranin B causes the stagnation of normal cells, but it can cause the death of transformed cells .

HY-119736

Leptolstatin	Others	Others
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .

HY-130403

Leptocarpin acetate	Others	Others
Leptocarpin acetate is an active compound.

HY-N13754

Leptostachyol acetate	Parasite	Infection
Leptostachyol acetate is a lignan compound that can be isolated from the roots of Phryma leptostachya var. asiatica. Leptostachyol acetate exhibits larvicidal activity against mosquito larvae, with LC₅₀ values of 0.41, 2.1, and 2.3 ppm against third instar larvae of Culex pipiens pallens, Aedes aegypti, and Ocheratatos togoi, respectively. Leptostachyol acetate can be used for research on mosquito larval control .

HY-114811

Leptophos oxon	Insecticide GABA Receptor Chloride Channel	Infection Neurological Disease
Leptophos oxon, a metabolite of leptophos, is a GABA_A receptor chloride channel inhibitor with an IC₅₀ values of 89.6 μM. Leptophos oxon inhibits GABA-induced chloride influx, binds to GABA_A receptor-associated TBPS sites, and inhibits TBPS binding to voltage-dependent chloride channels. Leptophos oxon is a insecticide. Leptophos oxon can be used for the research of neurological disease .

Cat. No.	Product Name	Target	Research Area

HY-P1523

Leptin (22-56), human	iGluR	Metabolic Disease
Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).

HY-P4736

Leptin (116-130) (human)	Peptides	Others
Leptin (116-130) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3340

Leptin (116-130)	iGluR	Neurological Disease
Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) .

HY-P2540

Leptin (93-105), human	Peptides	Metabolic Disease
Leptin (93-105), human, is the amino acids 93 to 105 fragment of human leptin. Leptin is a 167-residue peptide hormone mainly produced by adipocytes and acts in the central nervous system to primarily coordinate the metabolic adaptations to fasting .

Leptospermone	Leptospermum scoparium J. R. Forst. et G. Forst. Natural Products Myrtaceae Plants Source Classification	HPPD
Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC₅₀ of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect .

Tetrahydroharmine leptaflorine	Structural Classification Alkaloids Banisteriopsis caapi (Spruce ex Griseb.) Morton Malpighiaceae Plants Indole Alkaloids Source Classification	Monoamine Oxidase
Tetrahydroharmine (Leptaflorine) is a selective reversible monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 74 nM. Tetrahydroharmine can be used for the research of parkinson’s disease .

Leptomycin A	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	CRM1 HIV Antibiotic
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

Leptomerine	Alkaloids other families Quinoline Alkaloids Plants Source Classification	Cholinesterase (ChE)
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

Leptosperin	Leptospermum scoparium J. R. Forst. et G. Forst. Structural Classification Natural Products Myrtaceae Plants Source Classification	Bacterial
Leptosperin is a glycoside of methyl syringate found in manuka honey derived from the Leptospermum species Leptospermum scoparium. Leptosperin exhibits antibacterial activity. Leptosperin can be used for the research of infection .

Leptosphaerodione	Quinones Monophenols Microorganisms Classification of Application Fields Phenols Naphthalene Quinones Disease Research Fields Cancer Source Classification	Proteasome
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC₅₀ value of 3.2 μM. Anti-tumor agent .

Leptabiside C	Structural Classification Ketones, Aldehydes, Acids Rutaceae Melicope pteleifolia (Champ. ex Benth.) Hartley Plants Source Classification	Drug Derivative
Leptabiside C is a natural phenolic compound.

Leptabiside A	Structural Classification Rutaceae Phenols Polyphenols Melicope pteleifolia (Champ. ex Benth.) Hartley Plants Source Classification	Drug Derivative
Leptabiside A is a natural phenolic compound.

Leptofuranin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Leptofuranin D is found in the strain of Str. tanashiensis. Leptofuranin D causes the stagnation of normal cells, but it can cause the death of transformed cells .

Leptofuranin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Leptofuranin A is found in the strain of Str. tanashiensis. Leptofuranin A causes the stagnation of normal cells, but it can cause the death of transformed cells .

Leptofuranin C	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Leptofuranin C is found in the strain of Str. tanashiensis. Leptofuranin C causes the stagnation of normal cells, but it can cause the death of transformed cells .

Leptosin J	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Leptosin J is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin J inhibits Leukemia lymphocyte P388 in culture with an ED₅₀ of 1.25 μg/mL .

Leptodactylone	Structural Classification Rutaceae Coumarins Phenylpropanoids Citrus medica L. Plants Source Classification	Others
Leptodactylone is a compound isolated from the stem bark of Citrus medica L. var. sarcodactylis SWINGLE .

Leptofuranin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Leptofuranin B is found in the strain of Str. tanashiensis. Leptofuranin B causes the stagnation of normal cells, but it can cause the death of transformed cells .

Leptolstatin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .

Leptocarpin acetate	Terpenoids Sesquiterpenes Asteraceae Plants Calea divaricata Benth. Source Classification	Others
Leptocarpin acetate is an active compound.

Leptostachyol acetate	Structural Classification Lignans Phryma leptostachya subsp. asiatica (Hara)Kitamura Phrymaceae Phenylpropanoids Plants Source Classification	Parasite
Leptostachyol acetate is a lignan compound that can be isolated from the roots of Phryma leptostachya var. asiatica. Leptostachyol acetate exhibits larvicidal activity against mosquito larvae, with LC₅₀ values of 0.41, 2.1, and 2.3 ppm against third instar larvae of Culex pipiens pallens, Aedes aegypti, and Ocheratatos togoi, respectively. Leptostachyol acetate can be used for research on mosquito larval control .

Species:	Human (4) Rat (2) Mouse (3)
Tag:	His (7) Tag Free (3) Fc (1)
Source:	HEK293 (3) P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70704

	Leptin Protein, Mouse Maximum Cited Publications 7 Publications Verification leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Mouse	E. coli
	Leptin Protein, Mouse is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P70704A

	Leptin Protein, Mouse (His) 1 Publications Verification leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Mouse	E. coli
	Leptin is a key regulator of energy balance and body weight and binds to LEPR receptors in multiple tissues.It controls appetite in the hypothalamus and affects bone mass, hormone regulation, and reproductive function.Leptin Protein, Mouse (His) is the recombinant mouse-derived Leptin protein, expressed by E.coli , with N-6*His labeled tag.

HY-P70181

	Leptin Protein, Carassius auratus (P.pastoris, His) rCaleptin, His; leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Others	P. pastoris
	Leptin protein plays a pivotal role in regulating energy balance and body weight. It binds to its receptor, LEPR, in various tissues, activating signaling pathways that regulate energy homeostasis. Leptin Protein, Carassius auratus (P.pastoris, His) is the recombinant Leptin protein, expressed by P. pastoris , with N-8*His labeled tag.

HY-P73273

	Leptin R/LEPR Protein, Human (HEK293, His-Fc) leptin receptor; LEP-R; HuB219; OB-R; CD295; DB	Human	HEK293
	PSAP/prosaposin protein is a multifunctional protein involved in various cellular processes. It serves as a precursor to four different saponin proteins involved in lipid metabolism and lysosomal function. Leptin R/LEPR Protein, Human (HEK293, His-Fc) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag.

HY-P72523

	Leptin R/LEPR Protein, Mouse (HEK293, His) leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR	Mouse	HEK293
	Leptin R/LEPR protein, as a receptor for the hormone LEP/leptin, mediates central and peripheral effects by activating various signaling pathways (such as JAK2/STAT3 and MAPK cascade/FOS).In the hypothalamus, it regulates appetite, energy expenditure, bone mass, and hormone secretion.Leptin R/LEPR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P72524

	Leptin R/LEPR Protein, Human (HEK293, His) leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR	Human	HEK293
	Leptin R/LEPR protein, as the receptor of LEP/leptin, plays a key role in mediating central and peripheral effects through multiple signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, it regulates appetite, influencing orexigenic factors and inhibiting orexigenic neuropeptides. Leptin R/LEPR Protein, Human (HEK293, His) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P7232

	Leptin Protein, Human 2 Publications Verification rHuleptin; Obesity protein; OB	Human	E. coli
	Leptin is a cytokine-like sugar secretory protein secreted by adipocytes that helps regulate energy balance by inhibiting food intake and increasing thermogenesis. Leptin can activate the JAK2-STAT3 and PI3K-AKT/mTOR pathways to regulate energy metabolism, prolong the QT interval via MAPK in the myocardium, and play a protective role in the gastric mucosa by inducing NO/CGRP release via the vagus nerve. Circulating CRP protein binds to leptin and blocks signal transduction, leading to obesity resistance. Leptin Protein, Human is a recombinant human Leptin protein expressed by E. coli without a tag.

HY-P7233

	Leptin Protein, Rat 2 Publications Verification rRtleptin; Obesity protein (OB)	Rat	E. coli
	Leptin Protein, Rat is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P7232A

	Leptin Protein, Human (His) rHuleptin; Obesity protein; OB	Human	E. coli
	Leptin is a cytokine-like sugar secretory protein secreted by adipocytes that helps regulate energy balance by inhibiting food intake and increasing thermogenesis. Leptin can activate the JAK2-STAT3 and PI3K-AKT/mTOR pathways to regulate energy metabolism, prolong the QT interval via MAPK in the myocardium, and play a protective role in the gastric mucosa by inducing NO/CGRP release via the vagus nerve. Circulating CRP protein binds to leptin and blocks signal transduction, leading to obesity resistance. Leptin Protein, Human (His) is a recombinant human Leptin protein expressed by E. coli with N-6*His tag.

HY-P7233A

	Leptin Protein, Rat (His) rRtleptin; Obesity protein (OB)	Rat	E. coli
	Leptin Protein, Rat is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (3) Mouse (3) Sheep (1) Pig (1)
Application:	IHC-P (3) ICC/IF (2) IF-Tissue (1) WB (2) IHC-F (2) FC (1) ELISA (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (5)
Clonality:	Polyclonal (2) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85618

	Leptin Antibody (YA5310) FLJ94114; LEP; LEP_HUMAN; LEPD; leptin; murine obesity homolog; leptin; obesity homolog, mouse; leptin; leptin Murine Obesity Homolog; leptin Precursor Obesity Factor; OB; Obese Protein; Obese, mouse, homolog of; Obesity; Obesity factor; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog leptin; OBS; OTTHUMP00000212285.	ELISA	Human
	Leptin Antibody (YA5310) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Leptin.

HY-P85618A

	Leptin Antibody (YA5310)(PBS only) FLJ94114; LEP; LEP_HUMAN; LEPD; leptin; murine obesity homolog; leptin; obesity homolog, mouse; leptin; leptin Murine Obesity Homolog; leptin Precursor Obesity Factor; OB; Obese Protein; Obese, mouse, homolog of; Obesity; Obesity factor; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog leptin; OBS; OTTHUMP00000212285.	ELISA	Human
	Leptin Antibody (YA5310) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Leptin.

HY-P81241

	Leptin Antibody LEP; leptin Murine Obesity Homolog; leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog leptin; OBS; LEP_HUMAN.	IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat, Pig, Sheep
	Leptin Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Leptin.

HY-P82748

	Leptin Receptor Antibody (YA2493) leptin receptor; LEP-R; HuB219 OB receptor; OB-R; CD295; LEPR; DB; OBR	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Leptin Receptor Antibody (YA2493) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Leptin Receptor.

HY-P87658

	Leptin receptor Antibody	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	Leptin receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Leptin receptor.

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lept

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
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