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Cat. No.: HY-114811

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Leptophos oxon

Leptophos oxon, a metabolite of leptophos, is a GABA_A receptor chloride channel inhibitor with an IC₅₀ values of 89.6 μM. Leptophos oxon inhibits GABA-induced chloride influx, binds to GABA_A receptor-associated TBPS sites, and inhibits TBPS binding to voltage-dependent chloride channels. Leptophos oxon is a insecticide. Leptophos oxon can be used for the research of neurological disease.

For research use only. We do not sell to patients.

CAS No.: 25006-32-0
Formula: C₁₃H₁₀BrCl₂O₃P
Molecular Weight:396.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Leptophos oxon Chemical Structure

CAS No.: 25006-32-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GABAA

89.6 μM (IC₅₀)

In Vitro

Leptophos oxon (15 min pre-incubation) inhibits GABAa receptor-mediated ³⁶Cl^- influx in rat brain membrane microsacs with an IC₅₀ of 89.6 ± 30.4 μM^[2].
Leptophos oxon (90 min) inhibits [³⁵S]TBPS binding to rat brain GABAₐ receptors with an IC₅₀ of 13.4 ± 0.1 μM^[2].
Leptophos oxon (60 min) inhibits [³⁵S]TBPS binding to voltage-dependent Cl^- channels in Torpedo californica electric organ membranes with an IC₅₀ of 2.4 ± 0.1 μM, with maximum inhibition reaching 70-80% of control^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Leptophos oxon (25 mg/kg of leptophos (p.o.)) is a minor metabolite of leptophos in female Swiss mice, representing less than 1% of total recovered radioactivity and excreted exclusively in feces^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (female, 35-40 g)^[1]
Dosage:

Detected as metabolite of 25 mg/kg leptophos
Administration:

p.o. (leptophos administration)
Result:

Was detected only in mouse feces, accounting for 0.9% of total recovered radioactivity from phenoxy-labeled leptophos treatment.
Was detected only in mouse feces, accounting for 0.4% of total recovered radioactivity from phenyl-labeled leptophos treatment.

Chemical Information

CAS No. 25006-32-0
Molecular Weight 396.00
Formula C₁₃H₁₀BrCl₂O₃P
SMILES

O=P(C1=CC=CC=C1)(OC)OC2=CC(Cl)=C(Br)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Holmstead R L, et al. The metabolism of O-(4-bromo-2, 5-dichlorophenyl) O-methyl phenylphosphonothioate (leptophos) in white mice and on cotton plants[J]. Archives of Environmental Contamination and Toxicology, 1973, 1(2): 133-147.

[2]. Gant DB, et al. Action of organophosphates on GABAA receptor and voltage-dependent chloride channels. Fundam Appl Toxicol. 1987;9(4):698-704. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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