Leptophos oxon 

Leptophos oxon, a metabolite of leptophos, is a GABA_A receptor chloride channel inhibitor with an IC₅₀ values of 89.6 μM. Leptophos oxon inhibits GABA-induced chloride influx, binds to GABA_A receptor-associated TBPS sites, and inhibits TBPS binding to voltage-dependent chloride channels. Leptophos oxon is a insecticide. Leptophos oxon can be used for the research of neurological disease^[2].

Leptophos oxon (15 min pre-incubation) inhibits GABAa receptor-mediated ³⁶Cl^- influx in rat brain membrane microsacs with an IC₅₀ of 89.6 ± 30.4 μM^[2].
Leptophos oxon (90 min) inhibits [³⁵S]TBPS binding to rat brain GABAₐ receptors with an IC₅₀ of 13.4 ± 0.1 μM^[2].
Leptophos oxon (60 min) inhibits [³⁵S]TBPS binding to voltage-dependent Cl^- channels in Torpedo californica electric organ membranes with an IC₅₀ of 2.4 ± 0.1 μM, with maximum inhibition reaching 70-80% of control^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leptophos oxon (25 mg/kg of leptophos (p.o.)) is a minor metabolite of leptophos in female Swiss mice, representing less than 1% of total recovered radioactivity and excreted exclusively in feces^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.00

C₁₃H₁₀BrCl₂O₃P

25006-32-0

O=P(C1=CC=CC=C1)(OC)OC2=CC(Cl)=C(Br)C=C2Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Holmstead R L, et al. The metabolism of O-(4-bromo-2, 5-dichlorophenyl) O-methyl phenylphosphonothioate (leptophos) in white mice and on cotton plants[J]. Archives of Environmental Contamination and Toxicology, 1973, 1(2): 133-147.

  [2]. Gant DB, et al. Action of organophosphates on GABAA receptor and voltage-dependent chloride channels. Fundam Appl Toxicol. 1987;9(4):698-704.  [Content Brief]