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Results for "

myeloperoxidase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Adenosine Receptor (1) Apoptosis (5) Bacterial (12) Cathepsin (1) CFTR (3) Chloride Channel (3) COX (2) Cytochrome P450 (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (3) Endogenous Metabolite (9) Fluorescent Dye (1) Fungal (1) Glutathione Peroxidase (22) Glutathione S-transferase (2) Glycosidase (1) Interleukin Related (6) Isotope-Labeled Compounds (3) Leukotriene Receptor (1) Microtubule/Tubulin (1) Na+/K+ ATPase (1) Necroptosis (1) NF-κB (1) NO Synthase (3) Nuclear Factor of activated T Cells (NFAT) (2) p38 MAPK (2) Pantetheinase (1) Phosphatase (7) Reference Standards (4) SOD (2) TGF-β Receptor (1) TNF Receptor (5)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (12) Inflammation/Immunology (30) Metabolic Disease (7) Neurological Disease (3)

By Targets:

Adenosine Kinase (1)

Adenosine Receptor (1)

Apoptosis (5)

Bacterial (12)

Cathepsin (1)

CFTR (3)

Chloride Channel (3)

COX (2)

Cytochrome P450 (1)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (3)

Endogenous Metabolite (9)

Fluorescent Dye (1)

Fungal (1)

Glutathione Peroxidase (22)

Glutathione S-transferase (2)

Glycosidase (1)

Interleukin Related (6)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (1)

Microtubule/Tubulin (1)

Na+/K+ ATPase (1)

Necroptosis (1)

NF-κB (1)

NO Synthase (3)

Nuclear Factor of activated T Cells (NFAT) (2)

p38 MAPK (2)

Pantetheinase (1)

Phosphatase (7)

Reference Standards (4)

SOD (2)

TGF-β Receptor (1)

TNF Receptor (5)

By Research Areas:

Cancer (6)

Cardiovascular Disease (3)

Infection (12)

Inflammation/Immunology (30)

Metabolic Disease (7)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-P2818E

Alkaline Phosphatase, Calf intestinal 1 Publications Verification Apase, Calf intestinal	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces *myeloperoxidase* activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation .

HY-114360A

Taurohyodeoxycholic acid sodium 2 Publications Verification	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-B0679

Lubiprostone 1 Publications Verification RU-0211; SPI-0211	Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-125859A

Myeloperoxidase, human white blood cells 1 Publications Verification MPO	Bacterial	Inflammation/Immunology
Myeloperoxidase, human white blood cells (MPO) is a peroxidase. In Myeloperoxidase, human white blood cells mediate oxidative stress by promoting the production of reactive oxygen species (ROS) and active nitrogen (RNS), regulating the polarization and inflammation-related signaling pathways of microglia and neutrophils. Myeloperoxidase, human white blood cells has antibacterial activity .

HY-N3029

Noreugenin 2 Publications Verification	Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase Necroptosis	Inflammation/Immunology
Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits *myeloperoxidase* activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy .

HY-N4288

4-Methylesculetin 3 Publications Verification	Glutathione Peroxidase Cathepsin Phosphatase	Inflammation/Immunology Cancer
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits *myeloperoxidase* activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-145581

Mitiperstat 1 Publications Verification AZD4831	Glutathione Peroxidase Cytochrome P450	Cardiovascular Disease Inflammation/Immunology
Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC₅₀s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC₅₀ of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease .

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dye Glutathione Peroxidase	Others
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of *myeloperoxidase*. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-N0656

Usnic acid 2 Publications Verification	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis	Infection Inflammation/Immunology Cancer
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-P2818C

Alkaline phosphatase, microorganism 1 Publications Verification Apase, microorganism	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline Phosphatase (Apase), microorganism is an alkaline phosphatase from microorganism, and is one of the most active alkaline phosphatases. Alkaline phosphatase, microorganism is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, microorganism reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, microorganism improves survival rate of mice infected with E. coli. Alkaline phosphatase, microorganism improves TNBS-induced colon inflammation .

HY-P2818A

Alkaline phosphatase, Escherichia coli 1 Publications Verification Apase, Escherichia coli	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline Phosphatase (Apase), Escherichia coli is an alkaline phosphatase from Escherichia coli, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Escherichia coli is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Escherichia coli improves survival rate of mice infected with E. coli. Alkaline phosphatase, Escherichia coli improves TNBS-induced colon inflammation .

HY-N11552

Sorbifolin	Glutathione Peroxidase	Inflammation/Immunology
Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC₅₀ value of 19.2 nM .

HY-139915

MPO-IN-1	Glutathione Peroxidase	Inflammation/Immunology
MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC₅₀s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation .

HY-N6937

(R,R)-Secoisolariciresinol diglucoside 1 Publications Verification (R,R)-SDG; (R,R)-LGM2605	Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N0902

Dihydrosanguinarine 13,14-Dihydrosanguinarine	Fungal Bacterial Interleukin Related	Infection Inflammation/Immunology
Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis .

HY-105017

Evodenoson ATL 313; DE 112	Adenosine Receptor	Infection Inflammation/Immunology
Evodenoson is a selective agonist of the A_2A adenosine receptor. Evodenoson’s primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenoson’s protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) .

HY-P2818B

Alkaline phosphatase, Chicken Intestine 1 Publications Verification Apase, Chicken Intestine	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline Phosphatase (Apase), Chicken Intestine is an alkaline phosphatase from Chicken Intestine, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Chicken Intestine is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Chicken Intestine reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Chicken Intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Chicken Intestine improves TNBS-induced colon inflammation .

HY-W996116

AZM198	Glutathione Peroxidase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC₅₀=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .

HY-116005

A-286501	Adenosine Kinase	Neurological Disease Inflammation/Immunology
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC₅₀ value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .

HY-W023331

(R)-b-Aminoisobutyric acid	Glutathione Peroxidase Bacterial	Infection
(R)-β-Aminoisobutyric acid is a β-amino acid. (R)-β-Aminoisobutyric acid boosts *myeloperoxidase* microbicidal activity against susceptible microorganisms. (R)-β-Aminoisobutyric acid can be used for the research of bacterial infections .

HY-N0656R

Usnic acid (Standard)	Reference Standards Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis	Infection Inflammation/Immunology Cancer
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-159986

X-17	Pantetheinase	Cancer
X-17 is a Vanin-1 Inhibitor with potent anti-inflammatory and antioxidant activities. X-17 repressrs the inflammatory factor expressions and myeloperoxidase activity, elevats the colonic glutathione reserve, and restors the intestinal barrier .

HY-N4280

7,8-Dimethoxycoumarin 1 Publications Verification	Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology
7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H ⁺/K ⁺-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .

HY-112740

SC-53228	Leukotriene Receptor	Inflammation/Immunology
SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis .

HY-163335

MPO-IN-7	Glutathione Peroxidase Dipeptidyl Peptidase Glycosidase	Cardiovascular Disease Inflammation/Immunology
MPO-IN-7 (compound MDC) is a *myeloperoxidase* inhibitor with the IC₅₀ values of 41 μM, 25 μM and 4.5 μM towards α-Glucosidase, dipeptidyl peptidase-4 and myeloperoxidase, respectively. MPO-IN-7 shows antioxidant and anti-inflammatory activity in vitro .

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium	Isotope-Labeled Compounds TNF Receptor Interleukin Related	Inflammation/Immunology
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-168002

MPO-IN-8	Glutathione Peroxidase	Inflammation/Immunology
MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels .

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-171183

AB8939	Microtubule/Tubulin Apoptosis	Cancer
AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC₅₀ of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells .

HY-B0679R

Lubiprostone (Standard) RU-0211 (Standard); SPI-0211 (Standard)	Reference Standards Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone (Standard) is the analytical standard of Lubiprostone. This product is intended for research and analytical applications. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-N6937R

(R,R)-Secoisolariciresinol diglucoside (Standard) (R,R)-SDG (Standard); (R,R)-LGM2605 (Standard)	Reference Standards Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6 (R,R)-SDG-d₆; (R,R)-LGM2605-d₆	Isotope-Labeled Compounds	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-B0679S

Lubiprostone-d7 RU-0211-d₇; SPI-0211-d₇	Isotope-Labeled Compounds Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-N3029R

Noreugenin (Standard)	Reference Standards Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase	Inflammation/Immunology
Noreugenin (Standard) is the analytical standard of Noreugenin. This product is intended for research and analytical applications. Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits *myeloperoxidase* activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy .

HY-103388

NCX 466	COX TGF-β Receptor Glutathione Peroxidase	Inflammation/Immunology
NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-β (TGF-β) and oxidative stress markers (such as thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase (MPO) activity, thereby preventing bleomycin (HY-108345)-induced pulmonary fibrosis in mice .

HY-169067

10-Methoxy-canthin-6-one Mtx-C	DNA/RNA Synthesis p38 MAPK Bacterial	Infection Cancer
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML) .

HY-E71006

Myeloperoxidase Isoform A, Human	Endogenous Metabolite	Metabolic Disease
Myeloperoxidase Isoform A, Human (EC 1.11.1.7) is a peroxidase. Myeloperoxidase is most abundantly expressed in neutrophils (a subtype of leukocytes) and produces hypohalous acid to exert its antibacterial activity.

HY-E71007

Myeloperoxidase Isoform B, Human	Endogenous Metabolite	Metabolic Disease
Myeloperoxidase Isoform B, Human (EC 1.11.1.7) is a peroxidase. Myeloperoxidase is most abundantly expressed in neutrophils (a subtype of leukocytes) and produces hypohalous acid to exert its antibacterial activity.

HY-E71008

Myeloperoxidase Isoform C, Human	Endogenous Metabolite	Metabolic Disease
Myeloperoxidase Isoform C, Human (EC 1.11.1.7) is a peroxidase. Myeloperoxidase is most abundantly expressed in neutrophils (a subtype of leukocytes) and produces hypohalous acid to exert its antibacterial activity.

HY-P2818F

Alkaline phosphatase, Human (HEK293) Apase, Human (HEK293)	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline phosphatase (Apase), Human (HEK293) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase improves survival rate of mice infected with E. coli. Alkaline phosphatase improves TNBS-induced colon inflammation .

Cat. No.	Product Name	Type

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dyes
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of *myeloperoxidase*. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

Cat. No.	Product Name	Type

HY-114360A

Taurohyodeoxycholic acid sodium 2 Publications Verification	Biochemical Assay Reagents
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-N3029

Noreugenin 2 Publications Verification	Structural Classification Natural Products Rhododendron dauricum Linn. Classification of Application Fields Plants Aloe arborescens Liliaceae Other Diseases Phenols Polyphenols Ericaceae Disease Research Fields Source Classification	Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase Necroptosis
Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits *myeloperoxidase* activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy .

HY-N4288

4-Methylesculetin 3 Publications Verification	Structural Classification Nicotiana tabacum L. Classification of Application Fields Coumarins Phenols Polyphenols Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification Cancer	Glutathione Peroxidase Cathepsin Phosphatase
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits *myeloperoxidase* activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-N0656

Usnic acid 2 Publications Verification	Infection Natural Products Classification of Application Fields Usnea diffracta Vain. Sunscreen Phenols Polyphenols Cosmetic Research Plants Disease Research Fields Usneaceae Source Classification	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-N11552

Sorbifolin	Pterogyne nitens Tul. Leguminosae Plants Source Classification	Glutathione Peroxidase
Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC₅₀ value of 19.2 nM .

HY-N6937

(R,R)-Secoisolariciresinol diglucoside 1 Publications Verification (R,R)-SDG; (R,R)-LGM2605	Linum usitatissimum Linn. Classification of Application Fields Linaceae Lignans Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N0902

Dihydrosanguinarine 13,14-Dihydrosanguinarine	Infection Alkaloids Structural Classification Classification of Application Fields Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Source Classification	Fungal Bacterial Interleukin Related
Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis .

HY-W023331

(R)-b-Aminoisobutyric acid	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Glutathione Peroxidase Bacterial
(R)-β-Aminoisobutyric acid is a β-amino acid. (R)-β-Aminoisobutyric acid boosts *myeloperoxidase* microbicidal activity against susceptible microorganisms. (R)-β-Aminoisobutyric acid can be used for the research of bacterial infections .

HY-N0656R

Usnic acid (Standard)	Structural Classification Natural Products Usnea diffracta Vain. Phenols Polyphenols Plants Usneaceae Source Classification	Reference Standards Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-N4280

7,8-Dimethoxycoumarin 1 Publications Verification	Structural Classification Classification of Application Fields Rutaceae Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Source Classification	Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H ⁺/K ⁺-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .

HY-N6937R

(R,R)-Secoisolariciresinol diglucoside (Standard) (R,R)-SDG (Standard); (R,R)-LGM2605 (Standard)	Structural Classification Linum usitatissimum Linn. Linaceae Lignans Phenylpropanoids Plants Source Classification	Reference Standards Others
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N3029R

Noreugenin (Standard)	Aloe arborescens Structural Classification Natural Products Liliaceae Rhododendron dauricum Linn. Phenols Polyphenols Ericaceae Plants Source Classification	Reference Standards Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase
Noreugenin (Standard) is the analytical standard of Noreugenin. This product is intended for research and analytical applications. Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits *myeloperoxidase* activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy .

Cat. No.	Product Name	Chemical Structure

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6

(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

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