10-Methoxy-canthin-6-one
Based on 1 Customer Validation
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML).
For research use only. We do not sell to patients.
- Purity: 98.71%
- CAS No.: 86293-40-5
- Formula: C15H10N2O2
- Molecular Weight:250.25
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Immunology/Inflammation Compound Library
HY-L007
-
MAPK Compound Library
HY-L010
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Oxygen Sensing Compound Library
HY-L045
-
Antibacterial Compound Library
HY-L049
-
Pyroptosis Compound Library
HY-L059
-
Anti-Lung Cancer Compound Library
HY-L075
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Angiogenesis-Related Compound Library
HY-L088
-
Osteogenesis Compound Library
HY-L131
-
Pain-Related Compound Library
HY-L139
-
Extracellular Vesicles (EVs) Compound Library
HY-L168
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
All DNA/RNA Synthesis Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
1.58 μg/mL
Compound: 43
|
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
|
[PMID: 34332400] |
| HCC1395 | IC50 |
14.7 μg/mL
Compound: 43
|
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
|
[PMID: 34332400] |
| KB | ED50 |
2.1 μg/mL
Compound: 1, NSC-341584
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 6875577] |
10-Methoxy-canthin-6-one (0.9-15 μM, 72 h) inhibits the proliferation of AML cell lines Kasumi-1 and KG-1. With with EC50 values of 5.1 μM and 6.0 μM[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces G2/M phase cell cycle arrest in Kasumi-1 and KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) inhibits colony formation of KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) upregulates phosphorylation of DNA damage response proteins (ATR, Chk1, Chk2, p53, H2A.X) in Kasumi-1 and KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces myeloid differentiation in Kasumi-1 and KG-1 cells[1].
10-Methoxycanthin-6-one (12-14 h) inhibits Bacillus cereus, Ralstonia solanacearum and Pseudomonas syringae with MIC values of 3.91, 15.63 and 7.81 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Kasumi-1 and KG-1 cells
-
Concentration:2 and 4 μM
-
Incubation Time:72 h
-
Result:Increased G2/M phase cell accumulation.
Upregulated cyclin B1 phosphorylation and cyclin-dependent kinase inhibitors (p16, p21, p27).
Reduced Ki-67 expression and increased retinoblastoma protein (Rb) phosphorylatio.
-
Cell Line:Kasumi-1 and KG-1 cells
-
Concentration:2 and 4 μM
-
Incubation Time:72 h
-
Result:Increased expression of myeloid markers (PU.1, myeloperoxidase/MPO, CD15, CD11b, CD14).
Increased p38 MAPK phosphorylation.
Chemical Information
-
CAS No. 86293-40-5
-
Appearance Solid
-
Molecular Weight 250.25
-
Formula C15H10N2O2
-
Color Light yellow to green yellow
-
SMILES
O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
-
Synonyms
Mtx-C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 3.33 mg/mL (13.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9(35):37343-37354. [Content Brief]
[2]. Li N, et al. Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives. Molecules. 2019 Apr 19;24(8):1553. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9960 mL | 19.9800 mL | 39.9600 mL | 99.9001 mL |
| 5 mM | 0.7992 mL | 3.9960 mL | 7.9920 mL | 19.9800 mL | |
| 10 mM | 0.3996 mL | 1.9980 mL | 3.9960 mL | 9.9900 mL |
10-Methoxy-canthin-6-one Related Classifications
HY-169067 Related Classifications
Powered by Bioz