10-Methoxy-canthin-6-one
Based on 1 publication(s) in Google Scholar
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.71%
- CAS 番号: 86293-40-5
- 分子式: C15H10N2O2
- 分子量:250.25
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 10-Methoxy-canthin-6-one
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
1.58 μg/mL
Compound: 43
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Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
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[PMID: 34332400] |
| HCC1395 | IC50 |
14.7 μg/mL
Compound: 43
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Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
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[PMID: 34332400] |
| KB | ED50 |
2.1 μg/mL
Compound: 1, NSC-341584
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 6875577] |
体外実験
10-Methoxy-canthin-6-one (0.9-15 μM, 72 h) inhibits the proliferation of AML cell lines Kasumi-1 and KG-1. With with EC50 values of 5.1 μM and 6.0 μM[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces G2/M phase cell cycle arrest in Kasumi-1 and KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) inhibits colony formation of KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) upregulates phosphorylation of DNA damage response proteins (ATR, Chk1, Chk2, p53, H2A.X) in Kasumi-1 and KG-1 cells[1].
10-Methoxy-canthin-6-one (2-4 μM, 72 h) induces myeloid differentiation in Kasumi-1 and KG-1 cells[1].
10-Methoxycanthin-6-one (12-14 h) inhibits Bacillus cereus, Ralstonia solanacearum and Pseudomonas syringae with MIC values of 3.91, 15.63 and 7.81 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kasumi-1 and KG-1 cells
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Concentration:2 and 4 μM
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Incubation Time:72 h
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Result:Increased G2/M phase cell accumulation.
Upregulated cyclin B1 phosphorylation and cyclin-dependent kinase inhibitors (p16, p21, p27).
Reduced Ki-67 expression and increased retinoblastoma protein (Rb) phosphorylatio.
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Cell Line:Kasumi-1 and KG-1 cells
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Concentration:2 and 4 μM
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Incubation Time:72 h
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Result:Increased expression of myeloid markers (PU.1, myeloperoxidase/MPO, CD15, CD11b, CD14).
Increased p38 MAPK phosphorylation.
化学情報
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CAS 番号 86293-40-5
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性状 Solid
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分子量 250.25
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分子式 C15H10N2O2
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Color Light yellow to green yellow
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SMILES
O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
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別名
Mtx-C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 3.33 mg/mL (13.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9(35):37343-37354. [Content Brief]
[2]. Li N, et al. Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives. Molecules. 2019 Apr 19;24(8):1553. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9960 mL | 19.9800 mL | 39.9600 mL | 99.9001 mL |
| 5 mM | 0.7992 mL | 3.9960 mL | 7.9920 mL | 19.9800 mL | |
| 10 mM | 0.3996 mL | 1.9980 mL | 3.9960 mL | 9.9900 mL |
10-Methoxy-canthin-6-one 関連分類
HY-169067 関連分類
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