86293-40-5
Chemical Structure
10-Methoxy-canthin-6-one
Synonym(s): Mtx-C
- CAS No.: 86293-40-5
- Formula:C15H10N2O2
- Molecular Weight:250.25
InChIKey: FDBMONUDUKGKGY-UHFFFAOYSA-N
SMILES: O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
Biological Activity: 10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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10-Methoxy-canthin-6-one | 98.71% | 10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML). | ||||||||||||||||||||
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- [1]. Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9(35):37343-37354. [Content Brief]
- [2]. Li N, et al. Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives. Molecules. 2019 Apr 19;24(8):1553. [Content Brief]
Keywords
