2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis NF-κB MAPK/ERK Pathway Immunology/Inflammation
  3. Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
  4. 7,8-Dimethoxycoumarin

7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis.

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7,8-Dimethoxycoumarin

7,8-Dimethoxycoumarin Chemical Structure

CAS No. : 2445-80-9

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Based on 1 publication(s) in Google Scholar

7,8-Dimethoxycoumarin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 7,8-Dimethoxycoumarin

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis[1][2][3][4].

IC50 & Target[2][3]

NF-κB

 

IL-6

 

IL-8

 

In Vitro

7,8-Dimethoxycoumarin (DMC) protects human keratinocyte HaCaT cells from TNF-α-induced damage through inhibition of NF-κB activation and MAPK phosphorylation[2].
7,8-Dimethoxycoumarin stimulates melanogenesis via MAPK-mediated MITF upregulation and reduces IL-6, IL-8, and CCL2/MCP-1 expression in TNF-α-treated HaCaT cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7,8-Dimethoxycoumarin Related Antibodies
In Vivo

7,8-Dimethoxycoumarin (50-100 mg/kg; p.o.; daily; 6 consecutive days) ameliorates Cisplatin (HY-17394)-induced acute renal failure in male Sprague Dawley rats in a dose-dependent manner, with the 75 and 100 mg/kg doses producing significant renoprotective effects comparable to Cyclosporin A (HY-B0579)[1].
7,8-Dimethoxycoumarin (100-200 mg/kg; p.o.; daily; 10 consecutive days) dose-dependently attenuates TNF-α-induced trigeminal neuralgia in rats and reversing oxidative stress and histopathological damage[2].
7,8-Dimethoxycoumarin (50-100 mg/kg; i.p.; single dose 1 hour pre-ligation) exerts significant gastroprotective and anti-inflammatory effects in pyloric ligation-induced gastritis in rats at a dose of 100 mg/kg[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 180-250 g, cisplatin-induced)[1]
Dosage: 50 mg/kg; 75 mg/kg; 100 mg/kg
Administration: p.o.; daily; 6 consecutive days
Result: Reduced serum BUN, creatinine, urinary NAG, and renal TBARS levels at 50, 75, and 100 mg/kg in a dose‑dependent manner.
Increased FrNa, creatinine clearance, renal GSH, cytochrome c oxidase activity, and ATP levels, while decreasing renal total calcium at 50, 75, and 100 mg/kg.
Attenuated cisplatin‑induced renal histopathological damage; 75 and 100 mg/kg exhibited significant renoprotection comparable to cyclosporin A.
Animal Model: Sprague Dawley (male, 180-250 g, ischemia/reperfusion-induced)[1]
Dosage: 50 mg/kg; 75 mg/kg; 100 mg/kg
Administration: p.o.; daily; 6 consecutive days
Result: Reduced serum BUN, creatinine, urinary NAG, and renal TBARS levels at 50, 75, and 100 mg/kg in a dose‑dependent manner.
Increased FrNa, creatinine clearance, renal GSH, cytochrome c oxidase activity, and ATP levels, while lowering renal total calcium at 50, 75, and 100 mg/kg.
Attenuated ischemia/reperfusion‑induced renal histopathological damage; 75 and 100 mg/kg provided significant protection comparable to cyclosporin A.
Animal Model: Sprague Dawley (male, 180-250 g, cisplatin-induced or ischemia/reperfusion-induced)[1]
Dosage: 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: p.o.; single dose
Result: Did not produce preventive or protective effects against cisplatin- or ischemia/reperfusion-induced acute renal failure at 25, 50, or 100 mg/kg.
Animal Model: Wistar rats (male, middle-aged 12-14 months, 200-230 g, trigeminal neuralgia induced by single endoneural TNF-α injection)[2]
Dosage: 100 mg/kg; 200 mg/kg
Administration: p.o.; daily; 10 consecutive days
Result: Significantly reversed TNF-α-induced increases in percentage cold chemical sensitivity and percentage mechanical sensitivity response in a dose- and time-dependent manner.
Reduced trigeminal nerve TBARS and TNF-α levels while elevating GSH levels at 100 and 200 mg/kg.
Ameliorated TNF-α-induced histopathological alterations including axonal degeneration, neuronal hypertrophy, and neurovascular injury in trigeminal nerve tissue at both tested doses.
Animal Model: Wistar rats (either sex, fasted 24 hours prior to pyloric ligation)[4]
Dosage: 50 mg/kg; 75 mg/kg; 100 mg/kg
Administration: i.p.; single dose 1 hour pre-ligation
Result: Reduced gastric volume, total acidity, ulcerative index, TBARS levels, and MPO activity at 50, 75, and 100 mg/kg in a dose-dependent manner.
Increased GSH levels at 50, 75, and 100 mg/kg in a dose-dependent manner.
Exhibited effects comparable to omeprazole and N-acetylcysteine at 100 mg/kg.
Molecular Weight

206.19

Formula

C11H10O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC2=CC=C(OC)C(OC)=C2O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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7,8-Dimethoxycoumarin Related Classifications

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Keywords:

7,8-Dimethoxycoumarin2445-80-9Na+/K+ ATPaseGlutathione PeroxidaseNF-κBp38 MAPKInterleukin RelatedSodium potassium pumpNuclear factor-κBNuclear factor-kappaBILMITFratsMAPKtrigeminal neuralgiaH+/K+-ATPasemitochondrial permeability transition porehuman keratinocyte HaCaT cellsTNF-αacute renal failureInhibitorinhibitorinhibit

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