2445-80-9
Chemical Structure
7,8-Dimethoxycoumarin
- CAS No.: 2445-80-9
- Formula:C11H10O4
- Molecular Weight:206.19
IUPAC Name: 7,8-dimethoxy-2H-chromen-2-one
InChIKey: CHBBSMUTOCUVDW-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC=C(OC)C(OC)=C2O1
Biological Activity: 7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis[1][2][3][4].
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7,8-Dimethoxycoumarin | 99.75% | 7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis. | ||||||||||||||||||||
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- [1]. Muthuraman A, et al. Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats. Naunyn Schmiedebergs Arch Pharmacol. 2012;385(7):739-748. [Content Brief]
- [2]. Paramakrishnan N, et al. Therapeutic Potential of 7,8-Dimethoxycoumarin in Tumor Necrosis Factor-Alpha-Induced Trigeminal Neuralgia in a Rat Model. Curr Issues Mol Biol. 2025;47(7):518. Published 2025 Jul 4. [Content Brief]
- [3]. Kang JK, et al. 4-Hydroxy-7-Methoxycoumarin Inhibits Inflammation in LPS-activated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation. Molecules. 2020;25(19):4424. Published 2020 Sep 26. [Content Brief]
- [4]. Sood S. Role of 7,8-dimethoxycoumarin in anti-secretary and anti-inflammatory action on pyloric ligation-induced gastritis in rats. J Asian Nat Prod Res. 2010;12(7):593-599.
Keywords
