Myeloperoxidase, human white blood cells
Based on 1 publication(s) in Google Scholar
Myeloperoxidase, human white blood cells (MPO) is a peroxidase. In Myeloperoxidase, human white blood cells mediate oxidative stress by promoting the production of reactive oxygen species (ROS) and active nitrogen (RNS), regulating the polarization and inflammation-related signaling pathways of microglia and neutrophils. Myeloperoxidase, human white blood cells has antibacterial activity.
For research use only. We do not sell to patients.
- CAS No.: 9003-99-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-125859
Peroxidase, Horseradish -
HY-125859B
Lactoperoxidase, bovine milk -
HY-P1645
Papain -
HY-P2902
Glucose oxidase -
HY-129047C
TPCK-treated Trypsin -
HY-129047
Trypsin -
HY-P1635
Pepsin -
HY-129047A
Trypsin (MS grade) -
HY-P1645A
Papain (1.5-10 units/mg) -
HY-P1645B
Papain (lyophilized powder, ≥10 units/mg protein) -
HY-E70198
Pepsin (MS Grade) -
HY-108717
Proteinase K
Publications Citing Use of MedChemExpress (MCE) Myeloperoxidase, human white blood cells
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Biological Activity
Description
In Vitro
Product Information
This product is a lysosomal protein containing heme. The lyophilized product comes from 50 mM sodium acetate buffer, pH 6.0, containing 0.1M sodium chloride.
Instructions
Soluble in water, buffer (such as 50 mM sodium acetate), or according to specific experimental references. If frozen after dissolution, it will easily cause significant loss of enzyme activity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
1.11.1.7
Specific Activity
≥50 U/mg protein
Unit Definition
One unit is defined as the amount of enzyme that will catalyze the consumption of 1 μmol of hydrogen peroxide and the production of 1/4 μmol of tetraguaiacol per minute at pH 7.0 and 25°C
Chemical Information
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CAS No. 9003-99-0
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Appearance Solid
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Color Light yellow to yellow
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SMILES
[Myeloperoxidase, human white blood cells]
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Synonyms
MPO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Histol Histopathol
MPO-Mediated oxidative stress regulates lung tissue damage in T-COPD through activation of the NLRP3 inflammasome. [Abstract]2025 Oct 20:25006. PMID: 41111480
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen S, et al. Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds. Front Physiol. 2020 May 19;11:433. [Content Brief]
[2]. Parker H, et al. Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. J Leukoc Biol. 2012 Mar;91(3):369-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Myeloperoxidase, human white blood cells Related Classifications
HY-125859A Related Classifications
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