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nucleotide analog

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製品番号 製品名 Target 研究分野 構造式
  • HY-W406070
    2'-O,4'-C-Methyleneguanosine

    LNA-G

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products .
    2'-O,4'-C-Methyleneguanosine
  • HY-153128
    DOCK2-IN-1

    		DOCK Drug Derivative Inflammation/Immunology
    DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases .
    DOCK2-IN-1
  • HY-153845
    RNA Aptamer Broccoli sodium

    		Biochemical Assay Reagents Others
    RNA Aptamer Broccoli sodium is a 49-nucleotide nucleic acid aptamer that is much shorter than Spinach and Spinach2. It exhibits bright green fluorescence when binding to DFHBI or DFHBI-1T (a soluble analog of the green fluorescent protein label). RNA Aptamer Broccoli sodium can be used for RNA expression or localization in living cells .
    RNA Aptamer Broccoli sodium
  • HY-W011548
    2-Aminoadenosine

    		Nucleoside Antimetabolite/Analog Others
    2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .
    2-Aminoadenosine
  • HY-D1603
    BODIPY FL-EDA

    		Fluorescent Dye Others
    BODIPY FL-EDA is a widely used fluorescent dye for quantitative analysis of nucleotides. BODIPY FL-EDA is an aliphatic amine analog that can react with aldehydes and ketones. BODIPY FL-EDA can be used to detect both modified and unmodified deoxynucleotides and to determine DNA damage and genomic DNA methylation through capillary electrophoresis with laser-induced fluorescence (CE-LIF). Additionally, it can be used for quantifying intracellular ATP levels. The excitation wavelength is 500 nm, and the emission wavelength is 510 nm .
    BODIPY FL-EDA
  • HY-134320B
    8-Azido-ATP trisodium solution (100 mM)

    8-Azidoadenosine 5'-triphosphate trisodium; 8-N3-ATP trisodium

    		 Potassium Channel Metabolic Disease
    8-Azido-ATP (8-N3-ATP) trisodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP trisodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP trisodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
    8-Azido-ATP trisodium solution (100 mM)
  • HY-W570890
    2'-O-MOE-5-Me-C(Bz)

    		Phosphoramidites DNA/RNA Synthesis Others
    2'-O-MOE-5-Me-C(Bz) is a nucleotide analog that can be used for the synthesis of oligonucleotides.
    2'-O-MOE-5-Me-C(Bz)
  • HY-15745
    PSI-7409

    		HCV Cancer
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.
    PSI-7409
  • HY-137325A
    2-Chloro-ATP sodium

    		Calcium Channel Metabolic Disease
    2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
    2-Chloro-ATP sodium
  • HY-108548
    Rp-8-Br-PET-cGMPS sodium

    Rp-8-Bromo-PET-cGMPS

    		 PKG Inflammation/Immunology
    Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
    Rp-8-Br-PET-cGMPS sodium
  • HY-134320
    8-Azido-ATP

    8-Azidoadenosine 5'-triphosphate; 8-N3-ATP

    		 Potassium Channel Metabolic Disease
    8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    8-Azido-ATP
  • HY-171533
    LNA-CTP

    		Nucleoside Antimetabolite/Analog Others
    LNA-CTP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-CTP
  • HY-152448
    2’-Azido-2’-deoxycytidine

    		Nucleoside Antimetabolite/Analog Others
    2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
    2’-Azido-2’-deoxycytidine
  • HY-109014
    Tenofovir exalidex

    CMX-157

    		 HIV HBV Nucleoside Antimetabolite/Analog Infection
    Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV .
    Tenofovir exalidex
  • HY-109047
    Adafosbuvir

    AL-335

    		 HCV DNA/RNA Synthesis Infection
    Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase .
    Adafosbuvir
  • HY-113586
    Besifovir Dipivoxil

    LB-80380

    		 HBV DNA/RNA Synthesis Drug Derivative Infection
    Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .
    Besifovir Dipivoxil
  • HY-119151
    GS-9191

    		Apoptosis HPV DNA/RNA Synthesis Infection
    GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection .
    GS-9191
  • HY-171532
    LNA-ATP

    		Nucleoside Antimetabolite/Analog Others
    LNA-ATP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-ATP
  • HY-137695
    ddGTPαS

    		Nucleoside Antimetabolite/Analog Others
    ddGTPαS, a nucleotide analog, can be used for chain extension in PCR assays .
    ddGTPαS
  • HY-120816
    WU-07047

    		Calcium Channel Cardiovascular Disease
    WU-07047, a simplified analog of YM-254890 (HY-111557), is a selective Gαq/11 inhibitor. WU-07047 can inhibit nucleotide exchange .
    WU-07047
  • HY-137418
    2-MeS-ATP

    2-Methylthio-ATP

    		 P2Y Receptor Others Inflammation/Immunology
    2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases .
    2-MeS-ATP
  • HY-134263
    8-Br-cAMP-AM

    		PKA Ras Cardiovascular Disease
    8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .
    8-Br-cAMP-AM
  • HY-126877
    3-Deaza-2'-deoxyadenosine

    		HSV Infection
    3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity .
    3-Deaza-2'-deoxyadenosine
  • HY-116540A
    L 858051 dihydrochloride

    7DMB-Forskolin

    		 Adenylate Cyclase Cardiovascular Disease
    L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg 2+-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca 2+ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .
    L 858051 dihydrochloride
  • HY-101677
    cPrPMEDAP

    		Drug Metabolite Infection
    cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin .
    cPrPMEDAP
  • HY-109014R
    Tenofovir exalidex (Standard)

    CMX-157 (Standard)

    		 HIV HBV Nucleoside Antimetabolite/Analog Reference Standards Infection
    Tenofovir exalidex (Standard) is the analytical standard of Tenofovir exalidex. This product is intended for research and analytical applications. Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV .
    Tenofovir exalidex (Standard)
  • HY-106110
    OP-2507

    		Prostaglandin Receptor Metabolic Disease
    OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .
    OP-2507
  • HY-131799A
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium

    		Nucleoside Antimetabolite/Analog Others
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be used in the synthesis of other active compounds. The coumarin-labeled derivatives of 3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium exhibit significant fluorescence changes when interacting with myosin and can mimic the function of natural ADP .
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium
  • HY-171522
    LNA-AMP

    		Nucleoside Antimetabolite/Analog Others
    LNA-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-AMP
  • HY-171521
    LNA-GDP

    		Nucleoside Antimetabolite/Analog Others
    LNA-GDP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-GDP
  • HY-171535
    LNA-UTP

    		Nucleoside Antimetabolite/Analog Others
    LNA-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-UTP
  • HY-171534
    LNA-GTP

    		Nucleoside Antimetabolite/Analog Others
    LNA-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-GTP
  • HY-171523
    LNA-GMP

    		Nucleoside Antimetabolite/Analog Others
    LNA-GMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    LNA-GMP
  • HY-171525
    2'-F-CDP

    		Nucleoside Antimetabolite/Analog Others
    2'-F-CDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-CDP
  • HY-171526
    2′-F-UDP

    		Nucleoside Antimetabolite/Analog Others
    2′-F-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-F-UDP
  • HY-171527
    2′-OMe-ADP

    		Nucleoside Antimetabolite/Analog Others
    2′-OMe-ADP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-ADP
  • HY-171529
    2′-OMe-UDP

    		Nucleoside Antimetabolite/Analog Others
    2′-OMe-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-UDP
  • HY-171513
    2'-F-AMP

    		Nucleoside Antimetabolite/Analog Others
    2'-F-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2'-F-AMP
  • HY-171515
    2'-F-UMP

    		Nucleoside Antimetabolite/Analog Others
    2'-F-UMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2'-F-UMP
  • HY-171519
    2′-O-MOE-CMP

    		Nucleoside Antimetabolite/Analog Others
    2′-O-MOE-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-O-MOE-CMP
  • HY-171530
    2'-O-MOE-GTP

    		Nucleoside Antimetabolite/Analog Others
    2'-O-MOE-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-GTP
  • HY-171514
    2'-F-CMP

    		Nucleoside Antimetabolite/Analog Others
    2'-F-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2'-F-CMP
  • HY-171516
    2′-OMe-UMP

    		Nucleoside Antimetabolite/Analog Others
    2′-OMe-UMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2′-OMe-UMP
  • HY-171531
    2'-O-MOE-UTP

    		Nucleoside Antimetabolite/Analog Others
    2'-O-MOE-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-UTP
  • HY-171517
    2′-O-MOE-AMP

    		Nucleoside Antimetabolite/Analog Others
    2′-O-MOE-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2′-O-MOE-AMP
  • HY-171520
    2'-O-MOE-GMP

    		Nucleoside Antimetabolite/Analog Others
    2'-O-MOE-GMP is a nucleotide analog that can be used in the synthesis of oligonucleotides .
    2'-O-MOE-GMP
  • HY-177165
    3'-NH2-CTP

    		Nucleoside Antimetabolite/Analog Others
    3'-NH2-CTP is a nucleotide analog with an amino group modified at the 3' end of CTP.
    3'-NH2-CTP
  • HY-131759A
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium

    2'-NH2-ADP sodium

    		 Drug Derivative Nucleoside Antimetabolite/Analog Others
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide and a structural analog of the purine nucleotide ADP .
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
  • HY-W382140
    4′-C-Fluoro-2′-C-methyluridine

    		HCV Infection
    4′-C-Fluoro-2′-C-methyluridine is a nucleotide analog, which exhibits antiviral activity against hepatitis C virus (HCV) .
    4′-C-Fluoro-2′-C-methyluridine
  • HY-131824
    5,6-DM-cBIMP

    		Phosphodiesterase (PDE) Others
    5,6-DM-cBIMP, a cyclic nucleotide analog, is an agonist of PDE2 that can significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 [2.
    5,6-DM-cBIMP

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