8-Br-dGTP sodium
8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5), an 8-brominated purine nucleotide, is a syn-oriented analog of dGTP. 8-Br-dGTP sodium can be hydrolyzed by the enzyme hMTH1 protein (HY-P74740). 8-Br-dGTP sodium inhibits dGTP-activated ADP reduction with a Ki of 56 μM. 8-Br-dGTP sodium has no significant genotoxicity and mutagenic potentials during DNA synthesis.
For research use only. We do not sell to patients.
- Formula: C10H11BrN5Na4O13P3
- Molecular Weight:674.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 674.00
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Formula C10H11BrN5Na4O13P3
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SMILES
O[C@H]1C[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
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Synonyms
8-Bromo-dGTP sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kamiya H, et al. Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. J Mol Biol. 2004 Feb 27;336(4):843-50. [Content Brief]
[2]. Yin Y, et al. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation. Bioorg Med Chem. 2016 Aug 15;24(16):3856-61. [Content Brief]
[3]. Wu X, et al. Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2387-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-Br-dGTP sodium Related Classifications
HY-134273A Related Classifications
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