2. GPCR/G Protein
  3. P2Y Receptor
  4. 2-MeS-ATP

2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.

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2-MeS-ATP

2-MeS-ATP Chemical Structure

CAS No. : 43170-89-4

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2-MeS-ATP Related Antibodies

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Description

2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
1 nM
Compound: 2
Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
[PMID: 15317453]
Oocyte EC50
1500 nM
Compound: 2-MeSATP
Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
[PMID: 12213051]
Oocyte EC50
7400 nM
Compound: 2-MeSATP
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
[PMID: 12213051]
Molecular Weight

553.27

Formula

C11H18N5O13P3S
CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-MeS-ATP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MeS-ATP43170-89-42-Methylthio-ATPP2Y ReceptorAdenosine nucleotideAnalogueAgonistLPSInflammationP2Y Purinergic ReceptorInhibitorinhibitorinhibit

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