2-MeS-ATP
2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 43170-89-4
- Formula: C11H18N5O13P3S
- Molecular Weight:553.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All P2Y Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1 nM
Compound: 2
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Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
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[PMID: 15317453] |
| Oocyte | EC50 |
1500 nM
Compound: 2-MeSATP
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Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
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[PMID: 12213051] |
| Oocyte | EC50 |
7400 nM
Compound: 2-MeSATP
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Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
|
[PMID: 12213051] |
Chemical Information
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CAS No. 43170-89-4
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Molecular Weight 553.27
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Formula C11H18N5O13P3S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Synonyms
2-Methylthio-ATP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)