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Rp-8-Br-PET-cGMPS sodium

(Synonyms: Rp-8-Bromo-PET-cGMPS)
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Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

For research use only. We do not sell to patients.

  • Purity : 99.42%
  • CAS No.: 185246-32-6
  • Formula: C18H14BrN5NaO6PS
  • Molecular Weight:562.27
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Rp-8-Br-PET-cGMPS sodium Chemical Structure
    Rp-8-Br-PET-cGMPS sodium Chemical Structure
CAS No.: 185246-32-6
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Rp-8-Br-PET-cGMPS sodium Chemical Structure
    Rp-8-Br-PET-cGMPS sodium Chemical Structure
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  • Rp-8-Br-PET-cGMPS sodium