185246-32-6
Chemical Structure
Rp-8-Br-PET-cGMPS sodium
Synonym(s): Rp-8-Bromo-PET-cGMPS
- CAS 番号: 185246-32-6
- Formula:C18H14BrN5NaO6PS
- Molecular Weight:562.27
SMILES: BrC1=NC2=C(NC3=NC(C4=CC=CC=C4)=CN3C2=O)N1[C@@](O[C@@](CO5)([H])[C@@]6([H])O[P@@]5(S[Na])=O)([H])[C@@H]6O.[R]
Biological Activity: Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
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Rp-8-Br-PET-cGMPS sodium | 99.42% | Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11. | ||||||||||||||||||||
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