2. Immunology/Inflammation Others
  3. DOCK Drug Derivative
  4. DOCK2-IN-1

DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases.

For research use only. We do not sell to patients.

DOCK2-IN-1

DOCK2-IN-1 Chemical Structure

CAS No. : 4590-86-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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DOCK2-IN-1 Related Antibodies

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Description

DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases[1].

IC50 & Target[1]

DOCK2

19.1 μM (IC50)

In Vitro

DOCK2-IN-1 (0.1-100 μM; 2-30 min) potently inhibits the Rac1 guanine nucleotide exchange factor activity of purified DOCK2DHR-2 protein, with an IC50 of 19.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOCK2-IN-1 Related Antibodies
Molecular Weight

298.72

Formula

C16H11ClN2O2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (334.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3476 mL 16.7381 mL 33.4762 mL
5 mM 0.6695 mL 3.3476 mL 6.6952 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3476 mL 16.7381 mL 33.4762 mL 83.6904 mL
5 mM 0.6695 mL 3.3476 mL 6.6952 mL 16.7381 mL
10 mM 0.3348 mL 1.6738 mL 3.3476 mL 8.3690 mL
15 mM 0.2232 mL 1.1159 mL 2.2317 mL 5.5794 mL
20 mM 0.1674 mL 0.8369 mL 1.6738 mL 4.1845 mL
25 mM 0.1339 mL 0.6695 mL 1.3390 mL 3.3476 mL
30 mM 0.1116 mL 0.5579 mL 1.1159 mL 2.7897 mL
40 mM 0.0837 mL 0.4185 mL 0.8369 mL 2.0923 mL
50 mM 0.0670 mL 0.3348 mL 0.6695 mL 1.6738 mL
60 mM 0.0558 mL 0.2790 mL 0.5579 mL 1.3948 mL
80 mM 0.0418 mL 0.2092 mL 0.4185 mL 1.0461 mL
100 mM 0.0335 mL 0.1674 mL 0.3348 mL 0.8369 mL
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DOCK2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOCK2-IN-14590-86-7DOCKDrug DerivativeDedicator of cytokinesisDrug derivativechemotactic responseorgan-specific autoimmune diseasesguanine nucleotide exchange factor activityclassical GEFsRacT cell activationchemokine receptorlymphocytesantigen receptorDOCK2 DHR-2 domainInhibitorinhibitorinhibit

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HY-153128
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