4590-86-7
Chemical Structure
DOCK2-IN-1
- CAS No.: 4590-86-7
- Formula:C16H11ClN2O2
- Molecular Weight:298.72
IUPAC Name: (E)-4-(2-chlorobenzylidene)-1-phenylpyrazolidine-3,5-dione
InChIKey: VEBASGXAFMQOLL-JLHYYAGUSA-N
SMILES: O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
Biological Activity: DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DOCK2-IN-1 | 99.37% | DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases. | ||||||||||||||||||||
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Similarity Score 0.85
HY-110100CPYPP -
Similarity Score 0.67
HY-105592Phenopyrazone -
Similarity Score 0.63
HY-12649Y16 -
Similarity Score 0.62
HY-179228AN02 -
Similarity Score 0.62
HY-13297PYZD-4409 -
Similarity Score 0.61
HY-123590BC12-4 -
Similarity Score 0.61
HY-100858PP7 -
Similarity Score 0.60
HY-114911Feprazone -
Similarity Score 0.60
HY-136713Sirt1/2-IN-5 -
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