4590-86-7
Chemical Structure
DOCK2-IN-1
- CAS No.: 4590-86-7
- Formula:C16H11ClN2O2
- Molecular Weight:298.72
IUPAC Name: (E)-4-(2-chlorobenzylidene)-1-phenylpyrazolidine-3,5-dione
InChIKey: VEBASGXAFMQOLL-JLHYYAGUSA-N
SMILES: O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
Biological Activity: DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases[1].
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DOCK2-IN-1 | 99.37% | DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases. | ||||||||||||||||||||
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