2. Search Result
Search Result
Results for "

paw+edema

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

1

Peptides

9

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W021267
    3-Demethylcolchicine

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    3-Demethylcolchicine, a colchicine metabolite and anti-inflammatory agent, exhibits potent tubulin-binding activity. 3-Demethylcolchicine inhibits carrageenan-induced rat paw edema. 3-Demethylcolchicine bears a hydroxyl group on its carbocyclic ring; this group participates in free radical scavenging processes, allowing it to act as a free radical scavenger. 3-Demethylcolchicine is applicable to studies related to carrageenan-induced paw edema .
    3-Demethylcolchicine
  • HY-N10341
    Centaureidin

    		IFNAR ROCK Inflammation/Immunology Cancer
    Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice [1][2][3][4][5].
    Centaureidin
  • HY-N7694
    Isotoosendanin
    1 Publications Verification

    		 TGF-β Receptor JAK STAT Apoptosis Inflammation/Immunology Cancer
    Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
    Isotoosendanin
  • HY-N11072
    Tremulacin

    		Lipoxygenase Leukotriene Receptor Reactive Oxygen Species (ROS) MMP Inflammation/Immunology
    Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB4 and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases .
    Tremulacin
  • HY-116005
    A-286501

    		Adenosine Kinase Neurological Disease Inflammation/Immunology
    A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .
    A-286501
  • HY-127072
    Amicoumacin A

    		Antibiotic Bacterial Infection Inflammation/Immunology Cancer
    Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers [2] .
    Amicoumacin A
  • HY-N2478
    Taraxasteryl acetate

    		Autophagy Parasite Inflammation/Immunology
    Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment [1] [2] .
    Taraxasteryl acetate
  • HY-19295
    TRK-530 sodium

    		CXCR Inflammation/Immunology Endocrinology
    TRK-530 sodium is an orally active bisphosphonate. TRK-530 sodium inhibits CINC-1. TRK-530 sodium inhibits dental calculus formation. TRK-530 sodium also inhibits paw edema, joint destruction and osteomyelitis .
    TRK-530 sodium
  • HY-134521
    Diclofenac amide

    		COX Inflammation/Immunology
    Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
    Diclofenac amide
  • HY-124517
    Burimamide

    		Histamine Receptor Adrenergic Receptor Neurological Disease Inflammation/Immunology
    Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768) .
    Burimamide
  • HY-119298
    AW-814141

    		p38 MAPK Inflammation/Immunology
    AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis .
    AW-814141
  • HY-179429
    NLRP3-IN-85

    		NOD-like Receptor (NLR) TNF Receptor Interleukin Related Inflammation/Immunology
    NLRP3-IN-85 (compound 5d) is a potent NLRP3 inhibitor that targets mitochondria in a ΔΨm-independent manner. NLRP3-IN-85 protects mitochondria from oxidative stress and inflammation damage and suppresses key inflammatory factors (NO, TNF-α, IL-6). NLRP3-IN-85 relives acute lung injury in mice and inhibits paw edema in rats. NLRP3-IN-85 can be used for acute lung injury (ALI) research .
    NLRP3-IN-85
  • HY-116873
    Flunoxaprofen

    		COX Inflammation/Immunology
    Flunoxaprofen is an orally active COX inhibitor. Flunoxaprofen shows anti-inflammatory activity in a rat paw edema model. Flunoxaprofen may be used in research on immune system diseases such as arthritis .
    Flunoxaprofen
  • HY-116597
    L-783483

    F3MethylAA

    		 PPAR Inflammation/Immunology
    L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice .
    L-783483
  • HY-119279
    VUF 10214

    		Histamine Receptor Inflammation/Immunology
    VUF 10214 is a H4 receptor ligand with a pKi of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases .
    VUF 10214
  • HY-155405
    Anti-inflammatory agent 64

    		ROS Kinase Interleukin Related Inflammation/Immunology
    Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of IL-6 and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema .
    Anti-inflammatory agent 64
  • HY-N8458
    Cryogenine

    NSC 272693

    		 PGE synthase Inflammation/Immunology
    Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
    Cryogenine
  • HY-N2478R
    Taraxasteryl acetate (Standard)

    		Autophagy Reference Standards Inflammation/Immunology
    Taraxasteryl acetate (Standard) is the analytical standard of Taraxasteryl acetate. This product is intended for research and analytical applications. Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment .
    Taraxasteryl acetate (Standard)
  • HY-W747879
    Diclofenac Amide-13C6

    		Isotope-Labeled Compounds COX Inflammation/Immunology
    Diclofenac Amide- 13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
    Diclofenac Amide-13C6
  • HY-162166
    COX-2/15-LOX/mPGES1-IN-1

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .
    COX-2/15-LOX/mPGES1-IN-1
  • HY-117792
    LY314228

    		5-HT Receptor Inflammation/Immunology
    LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats. .
    LY314228
  • HY-D1782
    Selenomethylene blue

    		Fluorescent Dye Inflammation/Immunology
    Selenomethylene blue is an antioxidant and anti-inflammatory agent. Selenomethylene blue effectively inhibits the inflammatory paw edema in rats .
    Selenomethylene blue
  • HY-173114
    Anti-inflammatory agent 96

    		COX Inflammation/Immunology
    Anti-inflammatory agent 96 (Compound 5), a tetrasubstituted α-aminophosphonate derivatives with a methylphosphoserine fragment, is an anti-inflammatory agent. Anti-inflammatory agent 96 can reduce TPA-induced ear edema and CFA-induced paw edema .
    Anti-inflammatory agent 96
  • HY-175643
    COX-2-IN-58

    		COX Inflammation/Immunology
    COX-2-IN-58 is a COX-2 inhibitor. COX-2-IN-58 exhibits remarkable anti-inflammatory activity in Carrageenan (HY-125474)-induced paw edema model of Balb/C mice. COX-2-IN-58 can be used for the research of inflammation .
    COX-2-IN-58
  • HY-N19464
    Dicentrinone

    		PDI Inflammation/Immunology Cancer
    Dicentrinone is an orally active PDI inhibitor with an IC50 value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis .
    Dicentrinone
  • HY-119167
    Lotifazole

    F 1686

    		 COX Inflammation/Immunology
    Lotifazole (F 1686) is a non-steroidal anti-inflammatory agent. Lotifazole exhibits specific inhibition of delayed-type hypersensitivity and does not rely on the prostaglandin synthesis inhibition pathway at low doses. Lotifazole shows significant efficacy in treating paw edema induced by carrageenan in rats, erythema induced by ultraviolet radiation in guinea pigs, and pleurisy at high doses. Lotifazole can be used for the study of T-cell-mediated diseases .
    Lotifazole
  • HY-179700
    COX-2-IN-61

    		COX Inflammation/Immunology
    COX-2-IN-61 is an orally active COX-2 inhibitor with an IC50 of 22 µM, also inhibits COX-1 with an IC50 of 43 µM. COX-2-IN-61 exhibits anti-inflammation effects in a Carrageenan (HY-125474) induced rat paw edema model, with promising safety profiles. COX-2-IN-61 can be used for the research of inflammation .
    COX-2-IN-61
  • HY-180822
    COX-2-IN-63

    		COX TNF Receptor Interleukin Related Inflammation/Immunology
    COX-2-IN-63 (Compound 6k) is an orally active COX-2 inhibitor with an IC50 of 0.89 μM. COX-2-IN-63 reduces the levels of inflammatory mediators PGE2, TNF-α, and IL-6. COX-2-IN-63 can effectively alleviate acute inflammation in a rat paw edema model and has a lower risk of gastrointestinal side effects. COX-2-IN-63 can be used in anti-inflammatory research .
    COX-2-IN-63
  • HY-182786
    MAO-B-IN-56

    		Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX Amyloid-β Neurological Disease
    MAO-B-IN-56 is a multi-target-directed ligand with AChE, BChE, MAO-B, and BACE1 inhibitory activity, with IC50 values of 0.35 μM, 3.22 μM, 0.14 μM, and 3.85 μM respectively, and shows selectivity for AChE over BChE and MAO-B over MAO-A.MAO-B-IN-56 reduces amyloid-beta production, reduces paw edema, improves spatial memory, and enhances Alzheimer's disease hallmarks and associated histopathological alterations.MAO-B-IN-56 can be used for the research of alzheimer's disease .
    MAO-B-IN-56
  • HY-181235
    COX-2/Aromatase-IN-1

    		COX Cytochrome P450 Inflammation/Immunology Cancer
    COX-2/Aromatase-IN-1 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-1 can simultaneously inhibit COX-2 and aromatase, significantly suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-1 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-1 can be used for the study of inflammation and breast cancer .
    COX-2/Aromatase-IN-1
  • HY-181236
    COX-2/Aromatase-IN-2

    		COX Cytochrome P450 Inflammation/Immunology Cancer
    COX-2/Aromatase-IN-2 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-2 can simultaneously inhibit COX-2 and aromatase, suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-2 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-2 can be used for the study of inflammation and breast cancer .
    COX-2/Aromatase-IN-2
  • HY-N18124
    1-O-Tigloyl-1-O-debenzoylohchinal

    		Others Neurological Disease
    1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases .
    1-O-Tigloyl-1-O-debenzoylohchinal

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: