LY314228
LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats..
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- CAS. Nr.: 182633-54-1
- Formel: C20H24N4O3
- Molecular Weight:368.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
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5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
Chemical Information
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CAS. Nr. 182633-54-1
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Molecular Weight 368.43
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Formel C20H24N4O3
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SMILES
CCCC1=C(O)C(C(C)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LY314228 Related Classifications
HY-117792 Related Classifications
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