182633-54-1
Chemical Structure
LY314228
- CAS No.: 182633-54-1
- Formula:C20H24N4O3
- Molecular Weight:368.43
IUPAC Name: (E)-2-(4-((4-acetyl-3-hydroxy-2-propylbenzyl)oxy)benzylidene)hydrazine-1-carboximidamide
InChIKey: TUXHQPAMNGTVLT-FOKLQQMPSA-N
SMILES: CCCC1=C(O)C(C(C)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2
Biological Activity: LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats.[1].
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LY314228 | LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats.. | |||||||||||||||||||||
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