COX-2/Aromatase-IN-2
COX-2/Aromatase-IN-2 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-2 can simultaneously inhibit COX-2 and aromatase, suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-2 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-2 can be used for the study of inflammation and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1622452-45-2
- Formula: C16H13N3O3
- Molecular Weight:295.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-2 |
Aromatase |
COX-2/Aromatase-IN-2 (PM-4) (10, 20, 40, 80 μg/mL; 48 h) exerts significant anti-proliferative activity in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:10, 20, 40, 80 μg/mL
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Incubation Time:48 h
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Result:Exerted significant anti-proliferative activity against MCF-7 cells with the concentration of 80 μg/mL.
COX-2/Aromatase-IN-2 causes no obvious adverse reactions or mortality in Wistar albino rats, with good in vivo safety[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1622452-45-2
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Molecular Weight 295.29
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Formula C16H13N3O3
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SMILES
O=C(N1N=NC2=CC=CC=C21)/C=C/C3=CC=C(O)C(OC)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2/Aromatase-IN-2 Related Classifications
HY-181236 Related Classifications
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