2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Cytochrome P450
  4. COX-2/Aromatase-IN-1

COX-2/Aromatase-IN-1 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-1 can simultaneously inhibit COX-2 and aromatase, significantly suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-1 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-1 can be used for the study of inflammation and breast cancer.

For research use only. We do not sell to patients.

COX-2/Aromatase-IN-1

COX-2/Aromatase-IN-1 Chemical Structure

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COX-2/Aromatase-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

COX-2/Aromatase-IN-1 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-1 can simultaneously inhibit COX-2 and aromatase, significantly suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-1 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-1 can be used for the study of inflammation and breast cancer[1].

IC50 & Target[1]

COX-2

 

Aromatase

 

In Vitro

COX-2/Aromatase-IN-1 (PM-6) (10, 20, 40, 80 μg/mL; 48 h) induces 98.2% cell growth inhibition in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2/Aromatase-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 10, 20, 40, 80 μg/mL
Incubation Time: 48 h
Result: Induced 98.2% cell growth inhibition of MCF-7 cells at the concentration of 80 μg/mL.
In Vivo

COX-2/Aromatase-IN-1 (PM-6) exerts significant anti-inflammatory activity in carrageenan-induced paw edema model of Wistar albino rats[1].
COX-2/Aromatase-IN-1 causes no obvious adverse reactions or mortality in Wistar albino rats, with good in vivo safety[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

295.29

Formula

C16H13N3O3
SMILES

O=C(N1N=NC2=CC=CC=C21)/C=C/C3=CC=C(OC)C(O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2/Aromatase-IN-1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/Aromatase-IN-1COXCytochrome P450CyclooxygenaseCYPsCOX-2/Aromatase inhibitorinflammationbreast cancercell proliferation inhibitionMCF-7Wistar albino ratsInhibitorinhibitorinhibit

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