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Cat. No.: HY-182786

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MAO-B-IN-56

MAO-B-IN-56 is a multi-target-directed ligand with AChE, BChE, MAO-B, and BACE1 inhibitory activity, with IC₅₀ values of 0.35 μM, 3.22 μM, 0.14 μM, and 3.85 μM respectively, and shows selectivity for AChE over BChE and MAO-B over MAO-A.MAO-B-IN-56 reduces amyloid-beta production, reduces paw edema, improves spatial memory, and enhances Alzheimer's disease hallmarks and associated histopathological alterations.MAO-B-IN-56 can be used for the research of alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₆N₆O₅S
Molecular Weight:534.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAO-B-IN-56 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

AChE

0.35 μM (IC₅₀)

BChE

1.55 μM (IC₅₀)

BACE1

3.85 μM (IC₅₀)

MAO-A

0.85 μM (IC₅₀)

MAO-B

0.14 μM (IC₅₀)

COX-2

7.83 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

All Beta-secretase Isoforms :

BACE1
BACE2

All COX Isoforms :

In Vitro

MAO-B-IN-56 (Compound 3k) shows selectivity for AChE over BChE and MAO-B over MAO-A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MAO-B-IN-56 (Compound 3k) (0.028 mmol/kg; single administration) exhibits potent anti-inflammatory activity, reducing carrageenan-induced rat paw edema by 88.88% at 2 h post-induction^[1].
MAO-B-IN-56 (0.026 mmol/kg, administered daily) effectively ameliorates streptozotocin (STZ) (HY-13753)-induced Alzheimer's disease pathology in mice, enhances spatial memory, maintains hippocampal structural integrity, and normalizes key Alzheimer's disease (AD)-related biochemical parameters, but fails to restore recognition memory indicators in the novel object recognition (NOR) test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 534.59
Formula C₂₆H₂₆N₆O₅S
SMILES

COC1=CC=C(NC(CN2C=C(/C=N\NC(CNC3=CC=C(S(=O)(N)=O)C=C3)=O)C4=C2C=CC=C4)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Said MF, et al. In vitro, in vivo, and in silico profiling of optimized hydrazide-hydrazone indole congeners as multi-faceted AChE, BACE1, and MAO-B inhibitors for Alzheimer's disease therapy. Bioorg Chem. 2026;175:109774. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
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MAO-B-IN-56

All Cholinesterase (ChE) Isoforms

All Monoamine Oxidase Isoforms

All Beta-secretase Isoforms

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MAO-B-IN-56 Related Classifications

HY-182786 Related Classifications