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Art. -Nr.: HY-182786

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MAO-B-IN-56

MAO-B-IN-56 is a multi-target-directed ligand with AChE, BChE, MAO-B, and BACE1 inhibitory activity, with IC₅₀ values of 0.35 μM, 3.22 μM, 0.14 μM, and 3.85 μM respectively, and shows selectivity for AChE over BChE and MAO-B over MAO-A.MAO-B-IN-56 reduces amyloid-beta production, reduces paw edema, improves spatial memory, and enhances Alzheimer's disease hallmarks and associated histopathological alterations.MAO-B-IN-56 can be used for the research of alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₂₆N₆O₅S
Molecular Weight:534.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAO-B-IN-56 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

AChE

0.35 μM (IC₅₀)

BChE

1.55 μM (IC₅₀)

BACE1

3.85 μM (IC₅₀)

MAO-A

0.85 μM (IC₅₀)

MAO-B

0.14 μM (IC₅₀)

COX-2

7.83 μM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen :

MAO-A
MAO-B

Alle Beta-secretase Isoform-spezifische Produkte anzeigen :

BACE1
BACE2

Alle COX Isoform-spezifische Produkte anzeigen :

In Vitro

MAO-B-IN-56 (Compound 3k) shows selectivity for AChE over BChE and MAO-B over MAO-A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MAO-B-IN-56 (Compound 3k) (0.028 mmol/kg; single administration) exhibits potent anti-inflammatory activity, reducing carrageenan-induced rat paw edema by 88.88% at 2 h post-induction^[1].
MAO-B-IN-56 (0.026 mmol/kg, administered daily) effectively ameliorates streptozotocin (STZ) (HY-13753)-induced Alzheimer's disease pathology in mice, enhances spatial memory, maintains hippocampal structural integrity, and normalizes key Alzheimer's disease (AD)-related biochemical parameters, but fails to restore recognition memory indicators in the novel object recognition (NOR) test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 534.59
Formel C₂₆H₂₆N₆O₅S
SMILES

COC1=CC=C(NC(CN2C=C(/C=N\NC(CNC3=CC=C(S(=O)(N)=O)C=C3)=O)C4=C2C=CC=C4)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Said MF, et al. In vitro, in vivo, and in silico profiling of optimized hydrazide-hydrazone indole congeners as multi-faceted AChE, BACE1, and MAO-B inhibitors for Alzheimer's disease therapy. Bioorg Chem. 2026;175:109774. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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MAO-B-IN-56

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen

Alle Beta-secretase Isoform-spezifische Produkte anzeigen

Alle COX Isoform-spezifische Produkte anzeigen