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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
protease domain
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "protease domain" in MCE Product Catalog:
44
44 Publications Verification
Synonyms: VX-950
Target:
Research Areas:
Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CL pro activity .
2
2 Cited Publications
Cat. No.: HY-P73414
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLPI; Secretory Leukocyte protease Inhibitor (Antileukoproteinase); Secretory Leukocyte Peptidase Inhibitor; WAP Four-Disulfide Core domain Protein 4; WFDC4; Seminal Proteinase Inhibitor; BLPI; Mucus Proteinase Inhibitor; WAP4; protease Inhibitor WAP4; AL
Species:
Source:
1
1 Cited Publications
Cat. No.: HY-P99283
CAS No.: 1312299-39-0
Synonyms: NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody
1
1 Cited Publications
Cat. No.: HY-P72815
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ADAM17; Snake Venom-Like protease; Prev. TACE; ADAM Metallopeptidase domain 18; CSVP; Uncharacterized Protein ADAM17; Disintegrin And Metalloproteinase domain-Containing Protein 17; TNF-Alpha Converting Enzyme; TNF-Alpha Convertase; CD156b Antigen; CD156B
1
1 Cited Publications
Cat. No.: HY-P78717
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ADAM17; Snake Venom-Like protease; Prev. TACE; ADAM Metallopeptidase domain 18; CSVP; Uncharacterized Protein ADAM17; Disintegrin And Metalloproteinase domain-Containing Protein 17; TNF-Alpha Converting Enzyme; TNF-Alpha Convertase; CD156b Antigen; CD156B
1
1 Cited Publications
Cat. No.: HY-P71432
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WFDC2; WAP Four‑Disulfide Core domain 2; WAP5; HE4; WAP Four‑Disulfide Core domain Protein 2; DJ461P17.6; EDDM4; Major Epididymis‑Specific Protein E4; Putative protease Inhibitor WAP5; Epididymal Secretory Protein E4; Human Epididymis Protein 4; Epididyma
Synonyms: 113B7
PDZ1i (113B7) is a inhibitor of MDA-9/Syntenin, with selective binding to the PDZ1 domain. PDZ1i inhibits radiation-induced invasion of glioblastoma (GBM) cells, radiosensitizes GBM cells, and impairs GBM-related signaling pathways (including Src/EphA2, EGFRvIII/FAK, and NF-κB). PDZ1i reduces radiation-induced secretion of invasion-related proteases (MMP-2, MMP-9, ADAM9). PDZ1i shows anti-tumor effects in nude mice bearing intracranial U1242-luc xenografts or GBM xenografts. PDZ1i can be used for the study of glioblastoma (GBM), breast cancer and prostate cancer .
Cat. No.: HY-P3026
CAS No.: 37330-34-0
Research Areas:
The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.
Cat. No.: HY-124427
CAS No.: 83415-79-6
Category:
Quinones Plants Lithospermum erythrorhizon Sieb. et Zucc. Boraginaceae Naphthalene Quinones
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Cat. No.: HY-N12982
CAS No.: 21391-99-1
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Cat. No.: HY-P10383
CAS No.: 1621616-13-4
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Cat. No.: HY-P991696
CAS No.: 3037532-60-5
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Cat. No.: HY-10235S
Synonyms: VX-950-d4
Cat. No.: HY-155599
CAS No.: 2982527-11-5
HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .
Cat. No.: HY-10235R
CAS No.: 402957-28-2
Synonyms: VX-950 (Standard)
Target:
Research Areas:
Telaprevir (Standard) is the analytical standard of Telaprevir. This product is intended for research and analytical applications. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CLpro activity .
Cat. No.: HY-153573
Synonyms: dCym-JQ1
Target:
Research Areas:
SRG-II-19F (dCym-JQ1) is a BRDTBD1 PROTAC degrader. Its dCym moiety at one end binds to the N-terminal domain of ClpC1 (ClpC1NTD), while its JQ1 moiety at the other end binds to bromodomain 1 of BRDT (BRDTBD1). This molecule induces the degradation of BRDTBD1 by recruiting the BRDTBD1 substrate to the ClpC1P1P2 protease complex. SRG-II-19F serves as a research tool for studies related to mycobacterial protein degradation .
Cat. No.: HY-P10383A
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Cat. No.: HY-P992152
CAS No.: 897936-89-9
Synonyms: NN-1731
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Cat. No.: HY-184492
CAS No.: 3069129-78-5
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Research Areas:
HIV-IN-14 is an agent that binds to the HIV-1 reverse transcriptase p66 domain (monomeric GAG-POL), and also acts as a selective cytotoxic agent. HIV-IN-14 promotes GAG-POL dimerization, which in turn leads to premature activation of intracellular viral protease. HIV-IN-14 selectively kills HIV-infected cells expressing GAG-POL without exerting cytotoxicity on non-HIV-infected cells. HIV-IN-14 can be used in the research of HIV infection, acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
