2. Anti-infection
  3. SARS-CoV Virus Protease
  4. (+)-Adlumidine

(+)-Adlumidine (Adlumidine) is an isoquinoline alkaloid. (+)-Adlumidine efficiently binds to two key targets of SARS-CoV-2, Mpro and RBD, with IC50 values of 953.86 nM and 9.48 μM, respectively. (+)-Adlumidine exerts significant positive inotropic effects and certain positive chronotropic effects on cultured mouse embryonic cardiomyocytes. (+)-Adlumidine can be used for research on cardiovascular-related diseases and SARS-CoV-2 infection.

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(+)-Adlumidine

(+)-Adlumidine Chemical Structure

CAS No. : 550-49-2

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(+)-Adlumidine Related Antibodies

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Description

(+)-Adlumidine (Adlumidine) is an isoquinoline alkaloid. (+)-Adlumidine efficiently binds to two key targets of SARS-CoV-2, Mpro and RBD, with IC50 values of 953.86 nM and 9.48 μM, respectively. (+)-Adlumidine exerts significant positive inotropic effects and certain positive chronotropic effects on cultured mouse embryonic cardiomyocytes. (+)-Adlumidine can be used for research on cardiovascular-related diseases and SARS-CoV-2 infection.

Cellular Effect
Cell Line Type Value Description References
GES1 IC50
150 μM
Compound: 13
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
In Vitro

(+)-Adlumidine (0.03 mM; 5-20 min) increases the beating rate and amplitude of cultured embryonic ICR mouse myocardial cell sheets[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Adlumidine Related Antibodies
Molecular Weight

367.35

Formula

C20H17NO6
CAS No.
SMILES

CN1[C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(+)-Adlumidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Adlumidine550-49-2AdlumidineSARS-CoVVirus ProteaseSARS coronavirusembryonic mouse myocardial cell sheetsCys145/His41 catalytic dyadembryonic ICR mouse myocardial cell sheetsCR3022 epitopeSARS-CoV-2 spike protein receptor-binding domainRBDSARS-CoV-2 main proteaseACE2Mprocovid-19Inhibitorinhibitorinhibit

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