(+)-Adlumidine  (Synonyms: Adlumidine)

(+)-Adlumidine (Adlumidine) is an isoquinoline alkaloid. (+)-Adlumidine efficiently binds to two key targets of SARS-CoV-2, Mpro and RBD, with IC₅₀ values of 953.86 nM and 9.48 μM, respectively. (+)-Adlumidine exerts significant positive inotropic effects and certain positive chronotropic effects on cultured mouse embryonic cardiomyocytes. (+)-Adlumidine can be used for research on cardiovascular-related diseases and SARS-CoV-2 infection.

(+)-Adlumidine (0.03 mM; 5-20 min) increases the beating rate and amplitude of cultured embryonic ICR mouse myocardial cell sheets^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

367.35

C₂₀H₁₇NO₆

550-49-2

CN1[C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mousavi SS, et al. In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2. Molecules. 2021;26(18):5724. Published 2021 Sep 21.  [Content Brief]

  [2]. Kadota S, et al. Effects of alkaloids from Corydalis decumbens on contraction and electrophysiology of cardiac myocytes. Phytotherapy Research. 1996 Feb;10(1):18-22.