Successful, we will reply to you quickly.


Please select the quantity.


Your message is being sent, please wait.




Send mail failed, please send again!


Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Torin 1


(Torin1; Torin-1)

Torin 1

Torin 1 Chemical Structure

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $118 In-stock
10 mg $107 In-stock
50 mg $387 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €116 In-stock
10 mg €105 In-stock
50 mg €379 In-stock
100 mg Get quote
200 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: Torin 1
Cat. No.: HY-13003

Torin 1 Data Sheet

  • View current batch:

    Purity: 99.17%

  • Network Version


    Pdf Version Network Version


    Pdf Version


    Pdf Version


    Pdf Version


Customer View

Related Compound Libraries

Biological Activity of Torin 1

Torin 1 is potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.

Protocol (Extracted from published papers and Only for reference)


Chemical Information

M.Wt 607.64 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₃₅H₂₈F₃N₅O₂
CAS No 1222998-36-8
Solvent & Solubility

DMSO: ≤ 6.6 mg/mL (Need ultrasonic or warming)

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.6457 mL 8.2286 mL 16.4571 mL
5 mM 0.3291 mL 1.6457 mL 3.2914 mL
10 mM 0.1646 mL 0.8229 mL 1.6457 mL

References on Torin 1

1 . Timothy R. Peterson, Shomit S. Sengupta, Thurl E. Harris, Anne E. Carmack, Seong A. Kang, Eric Balderas, David A. Guertin, Katherine L. Madden, Anne E. Carpenter, Brian N. Finck, David M. Sabatini.mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.Cell, Volume 146, Issue 3, 408-420, 5 August 2011.
The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase. Dephosphorylated, nuclear, catalytically active lipin 1 promotes nuclear remodeling and mediates the effects of mTORC1 on SREBP target gene, SREBP promoter activity, and nuclear SREBP protein abundance. Inhibition of mTORC1 in the liver significantly impairs SREBP function and makes mice resistant, in a lipin 1-dependent fashion, to the hepatic steatosis and hypercholesterolemia induced by a high-fat and -cholesterol diet. These findings establish lipin 1 as a key component of the mTORC1-SREBP pathway.

Inhibitor Kit

Related mTOR Products

  • AP1903

    AP1903 is a homodimer binding to FKBP; elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM

  • AP20187

    AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.

  • AZD-8055

    AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM with excellent selectivity (~1,000-fold) against PI3K isoforms and ATM/DNA-PK.

  • AZD2014

    AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms ((alpha)/(beta)/(gamma)/(delta)).

  • CC-223

    CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K(alpha) (IC50=4 (mu)M).

  • CZ415

    CZ415 is a potent and highly selective mTOR inhibitor.

  • Deforolimus

    Deforolimus(AP23573; MK-8669; Ridaforolimus) is a selective mTOR inhibitor with IC50 of 0.2 nM; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin.

  • ETP-46464

    ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-K(alpha), and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).

  • Everolimus

    Everolimus (RAD001) is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

  • GDC-0084

    GDC-0084 is a potent, selective inhibitor of Class I PI3K and mTOR with good penetration across the blood-brain barrier.