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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Torin 1

HY-13003

(Torin1; Torin-1)

Torin 1

Torin 1 Chemical Structure

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K.

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10 mg $107 In-stock
50 mg $387 In-stock
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Free sample   Apply now  
10 mg €105 In-stock
50 mg €379 In-stock
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Product name: Torin 1
Cat. No.: HY-13003

Torin 1 Data Sheet

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    Purity: 99.17%

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Biological Activity of Torin 1

Torin 1 is potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 607.64 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C35H28F3N5O2
CAS No 1222998-36-8
Solvent & Solubility

DMSO: < 6.4 mg/mL; DMSO: ≥ 6 mg/mL (Need ultrasonic or warming)

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.6457 mL 8.2286 mL 16.4571 mL
5 mM 0.3291 mL 1.6457 mL 3.2914 mL
10 mM 0.1646 mL 0.8229 mL 1.6457 mL

References on Torin 1

1 . Timothy R. Peterson, Shomit S. Sengupta, Thurl E. Harris, Anne E. Carmack, Seong A. Kang, Eric Balderas, David A. Guertin, Katherine L. Madden, Anne E. Carpenter, Brian N. Finck, David M. Sabatini.mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.Cell, Volume 146, Issue 3, 408-420, 5 August 2011.
Abstract
The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase. Dephosphorylated, nuclear, catalytically active lipin 1 promotes nuclear remodeling and mediates the effects of mTORC1 on SREBP target gene, SREBP promoter activity, and nuclear SREBP protein abundance. Inhibition of mTORC1 in the liver significantly impairs SREBP function and makes mice resistant, in a lipin 1-dependent fashion, to the hepatic steatosis and hypercholesterolemia induced by a high-fat and -cholesterol diet. These findings establish lipin 1 as a key component of the mTORC1-SREBP pathway.

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