2. Membrane Transporter/Ion Channel Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. P2X Receptor Potassium Channel NO Synthase STAT Interleukin Related
  4. Tricarbonyldichlororuthenium(II) dimer

Tricarbonyldichlororuthenium(II) dimer  (Synonyms: CORM-2)

製品番号: HY-W033577 純度: 98.0%
COA 取扱説明書 Technical Support

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels.

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Tricarbonyldichlororuthenium(II) dimer

Tricarbonyldichlororuthenium(II) dimer 構造式

CAS 番号 : 22594-69-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
25 mg $50 在庫あり
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Based on 2 publication(s) in Google Scholar

Tricarbonyldichlororuthenium(II) dimer 関連抗体

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製品説明

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels[1][2][3][4].

体外実験

Tricarbonyldichlororuthenium(II) dimer (100 μM; 5-10 min) can activate non-selective cation currents in human umbilical vein endothelial cells, and this occurs independently of CO release[1].
Tricarbonyldichlororuthenium(II) dimer (12.5-100 μM; 3-48 h) exerts anti-inflammatory activity in RAW264.7 cells treated with LPS (Prevotella intermedia)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tricarbonyldichlororuthenium(II) dimer 関連抗体

Real Time qPCR[2]

Cell Line: LPS (Prevotella intermedia) treated RAW264.7 cells
Concentration: 12.5, 25, 50 and 100 μM
Incubation Time: 3 h
Result: Decreased the mRNA levels of iNOS and IL-1β.

Western Blot Analysis[2]

Cell Line: LPS (Prevotella intermedia) treated RAW264.7 cells
Concentration: 12.5, 25, 50 and 100 μM
Incubation Time: 4 h
Result: Inhibited the phosphorylation levels of STAT1 and STAT3.
体内実験

Tricarbonyldichlororuthenium(II) dimer (1-10 mg/kg; oral gavage; single dose) has a protective effect in a rat model of gastric mucosal injury induced by ischemia-reperfusion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute I/R gastric lesions treated male Wistar rats (250-300 g)[3]
Dosage: 1, 5 or 10 mg/kg
Administration: Oral gavage (i.g.); single dose
Result: Significantly decreased the area of I/R gastric damage and significantly increased GBF at doses of 1 or 5 mg/kg.
Significantly increased mRNA expression of HMOX-1 but not HMOX-2 in gastric mucosa and significantly increased blood concentration at dose of 5 mg/kg.
Significantly increased gastric mucosal PGE2 content at dose of 5 mg/kg.
Significantly decreased mRNA expression of iNOS but not eNOS in gastric mucosa at dose of 5 mg/kg.
Significantly decreased 8-hydroxyguanozine (8-OHG) concentration in gastric mucosa at dose of 5 mg/kg.
Decreased the expression of pro- and anti-inflammatory markers' mRNA and proteins at dose of 5 mg/kg.
分子量

512.01

分子式

C6H6Cl4O6Ru2
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

[O]#C[Ru+2](C#[O])([Cl-])([Cl-][Ru+2]1(C#[O])(C#[O])([Cl-])C#[O])([Cl-]1)C#[O]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 30 mg/mL (58.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9531 mL 9.7654 mL 19.5309 mL
5 mM 0.3906 mL 1.9531 mL 3.9062 mL
10 mM 0.1953 mL 0.9765 mL 1.9531 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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C2

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3 mg/mL (5.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 3 mg/mL (5.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 98.0%

COA (319 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9531 mL 9.7654 mL 19.5309 mL 48.8272 mL
5 mM 0.3906 mL 1.9531 mL 3.9062 mL 9.7654 mL
10 mM 0.1953 mL 0.9765 mL 1.9531 mL 4.8827 mL
15 mM 0.1302 mL 0.6510 mL 1.3021 mL 3.2551 mL
20 mM 0.0977 mL 0.4883 mL 0.9765 mL 2.4414 mL
25 mM 0.0781 mL 0.3906 mL 0.7812 mL 1.9531 mL
30 mM 0.0651 mL 0.3255 mL 0.6510 mL 1.6276 mL
40 mM 0.0488 mL 0.2441 mL 0.4883 mL 1.2207 mL
50 mM 0.0391 mL 0.1953 mL 0.3906 mL 0.9765 mL
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Tricarbonyldichlororuthenium(II) dimer Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tricarbonyldichlororuthenium(II) dimer22594-69-0CORM-2CORM2CORM 2P2X ReceptorPotassium ChannelNO SynthaseSTATInterleukin RelatedP2XRsKcsANitric oxide synthasesNOSILischemia-reperfusion modelhuman umbilical vein endothelial cellsRAW264.7 cellsInhibitorinhibitorinhibit

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Tricarbonyldichlororuthenium(II) dimer
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