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  4. Zinc picolinate

Zinc picolinate is an orally effective zinc supplement. Zinc picolinate reduces the expression of Hsp70, inhibits oxidative DNA damage, increases serum ALP activity, decreases MDA concentration, elevates SOD levels, and raises zinc concentrations in serum, whole body and plasma. Zinc picolinate does not alter copper and manganese contents in rainbow trout. Zinc picolinate exerts a protective effect against Acetic acid (HY-Y0319)-induced experimental colitis in Sprague Dawley rats. Zinc picolinate reduces uterine fibroid volume, alleviates colonic oxidative damage, relieves colonic inflammation, and enhances intestinal barrier integrity. Zinc picolinate can be used in research related to uterine fibroids, ulcerative colitis and chronic obstructive pulmonary disease.

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Zinc picolinate

Zinc picolinate Chemical Structure

CAS No. : 17949-65-4

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Zinc picolinate Related Antibodies

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Description

Zinc picolinate is an orally effective zinc supplement. Zinc picolinate reduces the expression of Hsp70, inhibits oxidative DNA damage, increases serum ALP activity, decreases MDA concentration, elevates SOD levels, and raises zinc concentrations in serum, whole body and plasma. Zinc picolinate does not alter copper and manganese contents in rainbow trout. Zinc picolinate exerts a protective effect against Acetic acid (HY-Y0319)-induced experimental colitis in Sprague Dawley rats. Zinc picolinate reduces uterine fibroid volume, alleviates colonic oxidative damage, relieves colonic inflammation, and enhances intestinal barrier integrity. Zinc picolinate can be used in research related to uterine fibroids, ulcerative colitis and chronic obstructive pulmonary disease[1][2][3][4].

IC50 & Target[1]

HSP70

 

In Vivo

Zinc picolinate (dietary supplementation at 30-60 mg zinc/kg; oral administration; ad libitum daily intake; for 350 days) significantly reduces the volume of spontaneous oviduct leiomyomas in Japanese quails, decreases the levels of systemic oxidative stress markers, and downregulates the expression of Hsp70 in leiomyoma tissues[1].
Zinc picolinate (dietary zinc content 30-60 mg Zn/kg; oral administration; twice daily; for 55 days) linearly reduces oxidative stress (measured by MDA concentration) in rainbow trout, increases their serum ALP activity and tissue zinc levels, and does not affect their growth, feed intake, feed efficiency, or copper/manganese concentrations[2].
Zinc picolinate (6 mg/kg; i.p.; once daily; for 10 consecutive days) exerts a protective effect against acetic acid-induced ulcerative colitis in male Sprague Dawley rats by alleviating oxidative stress, inhibiting local and systemic inflammation, enhancing intestinal barrier integrity, and improving histopathological outcomes, while significantly reducing colonic TNF-α levels and histopathological scores[3].
Zinc picolinate (6 mg/kg; i.p.; once daily; for 10 consecutive days) regulates the expression of colonic cytokines and tight junction proteins in healthy male Sprague Dawley rats, significantly increases colonic TNF-α levels, decreases colonic IL-6, occludin-1 and claudin-1 levels, and does not alter macroscopic or histopathological results[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Coturnix coturnix japonica (6-month-old)[1]
Dosage: 30 mg/kg of diet; 60 mg/kg of diet
Administration: p.o.; ad libitum daily; 350 days
Result: Showed no significant difference in tumor incidence between treatment and control groups (10% for 30 mg/kg group, 14% for 60 mg/kg group, vs. 16% control).
Reduced average tumor diameters significantly: 2.6 mm for the 30 mg/kg group and 2.9 mm for the 60 mg/kg group, compared to 4.8 mm in controls (P = .01).
Reduced serum oxidative stress markers significantly in a linear dose-dependent manner (P = .01): serum MDA was 1.34 μmol/L (30 mg/kg) and 0.93 μmol/L (60 mg/kg) vs. 1.95 μmol/L control; serum 8-isoprostane was 93 pg/mL (30 mg/kg) and 85 pg/mL (60 mg/kg) vs. 108 pg/mL control; serum HAE was 1.21 μmol/L (30 mg/kg) and 0.96 μmol/L (60 mg/kg) vs. 1.55 μmol/L control; serum 8-OHdG was 23.6 ng/mL (30 mg/kg) and 20.1 ng/mL (60 mg/kg) vs. 28.5 ng/mL control.
Decreased Hsp70 expression in fibroid tissue significantly in a dose-dependent manner (P < .05), with densitometric readings showing ~73% of control levels for the 30 mg/kg group and ~39% of control levels for the 60 mg/kg group.
Animal Model: Oncorhynchus mykiss (0+ y-old, initial average weight 50 g)[2]
Dosage: 30 mg Zn/kg of diet; 60 mg Zn/kg of diet
Administration: p.o.; twice daily; 55 days
Result: Decreased serum malondialdehyde (MDA) concentration to 1.12 nmol/mL, liver MDA to 3.30 nmol/mL, and muscle MDA to 2.15 nmol/mL at 30 mg Zn/kg of diet.
Decreased serum MDA concentration to 0.92 nmol/mL, liver MDA to 2.94 nmol/mL, and muscle MDA to 1.63 nmol/mL at 60 mg Zn/kg of diet.
Increased serum alkaline phosphatase (ALP) activity to 115 U/L, serum Zn concentration to 13.8 μg/mL, and whole body Zn concentration to 47.8 μg/g at 30 mg Zn/kg of diet.
Increased serum ALP activity to 138 U/L, serum Zn concentration to 15.6 μg/mL, and whole body Zn concentration to 52.0 μg/g at 60 mg Zn/kg of diet.
Did not significantly alter body weight gain, feed intake, feed efficiency, or serum/whole body Cu and Mn concentrations at either dose compared to unsupplemented controls.
Decreased serum, liver, and muscle MDA concentrations linearly (P=0.001) with increasing zinc picolinate dose.
Increased serum ALP activity (P=0.01), serum Zn (P=0.01), and whole body Zn (P=0.05) linearly with dose.
Animal Model: Sprague Dawley (male, 12-week-old, 250-300 g, acetic acid-induced ulcerative colitis)[3]
Dosage: 6 mg/kg
Administration: i.p.; daily; 10 days
Result: Attenuated ulcer severity and significantly reduced macroscopic damage score (p < 0.01) and stool consistency score (p < 0.05).
Significantly increased serum zinc levels (p < 0.05).
Significantly reduced colon malondialdehyde (MDA) levels (p < 0.05) and increased colon glutathione (GSH) levels (p < 0.01).
Significantly reduced colon myeloperoxidase (MPO) activity (p < 0.01), serum tumor necrosis factor (TNF)-α levels (p < 0.05), serum interleukin (IL)-6 levels (p < 0.01), colon TNF-α levels (p < 0.001), and colon IL-6 levels (p < 0.001).
Significantly increased colon occludin mRNA expression (p < 0.001) and claudin-1 mRNA expression (p < 0.001), and significantly reduced zonula occludens-1 mRNA expression (p < 0.001).
Significantly reduced histopathological score (p < 0.001) and increased PAS-positive surface mucus and goblet cell count.
Animal Model: Sprague Dawley (male, 12-week-old, 250-300 g)[3]
Dosage: 6 mg/kg
Administration: i.p.; daily; 10 days
Result: Showed no significant changes in macroscopic score, stool quality score, colonic edema score, colon MDA levels, colon GSH levels, colon MPO levels, serum TNF-α levels, serum IL-6 levels, or histopathological score compared to saline-treated healthy rats.
Significantly increased colon TNF-α levels (p < 0.05) and significantly reduced colon IL-6 levels (p < 0.01) compared to saline-treated healthy rats.
Significantly reduced colon occludin-1 mRNA expression (p < 0.001) and claudin-1 mRNA expression (p < 0.001) compared to saline-treated healthy rats; no significant change in zonula occludens mRNA expression.
Clinical Trial
Molecular Weight

309.58

Formula

C12H8N2O4Zn
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[O-][Zn+2]2([N]3=C1C=CC=C3)[O-]C(C4=[N]2C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinc picolinate17949-65-4SODHSPDNA/RNA SynthesisPhosphataseSuperoxide DismutaseHeat shock proteinsSprague Dawley ratsalkaline phosphatasetight junction proteinJapanese quailschronic obstructive pulmonary diseaseHsp70ulcerative colitisrainbow troutleiomyoma tissueleiomyomasInhibitorinhibitorinhibit

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