2. NF-κB Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
  4. α-Lipoic Acid sodium

α-Lipoic Acid sodium  (Synonyms: Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium)

Cat. No.: HY-N0492A Purity: 99.95%
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α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

For research use only. We do not sell to patients.

CAS No. : 2319-84-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
Solid
500 mg In-stock
1 g In-stock
5 g In-stock
10 g In-stock
50 g   Get quote  

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of α-Lipoic Acid sodium:

α-Lipoic Acid sodium Related Antibodies

Top Publications Citing Use of Products

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2025 Oct 31;15(1):150.  [Abstract]

    Response experiments were performed in TGF-β1-induced hEndoSCs using siBlk and ERS activator (α-Lipoic Acid (α-LA)), successively. Detection of the protein expression levels by Western blot. In TGF-β1-induced hEndoSCs, Collagen I and α-SMA expression were downregulated by BLK knockdown using siBLK, and such inhibitory effect was counteracted by the ERS agonist α-Lipoic Acid (α-LA, 100 μM; 24 h).

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2025 Oct 31;15(1):150.  [Abstract]

    Immunofluorescence detected the effect of intervention ERS on the expression of Collagen I (red) and α-SMA (green), respectively. DAPI (blue) was used to stain nuclei. The results showed that the ERS agonist α-Lipoic Acid (α-LA, 100 μM; 24 h) further upregulated the expression of Collagen I and α-SMA induced by TGF-β1.

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2025 Sep;33(9):5563-5581.  [Abstract]

    The macroscopic appearance and macroscopic scores of colon tissues were evaluated in all groups. Compared with the C group, the colon tissue damage characterized by ulceration, hyperemia and mucosal edema was significantly increased in the UC group, M group (50 mg/kg; oral gavage; once daily for 14 days; rats) and α-lipoic acid (ALA) group (100 mg/kg; oral gavage; once daily for 14 days; rats) (p < 0.01). The macroscopic score was lower in the M + ALA group than in other colitis-induced groups, although the difference was not statistically significant (*p* > 0.05).

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 14:155:114539.  [Abstract]

    SH-SY5Y cell viability reached 80% with α-Lipoic Acid (α-ALA) pretreatment at 150 μmol/L for 8 h.

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 14:155:114539.  [Abstract]

    TH and α-Synuclein Expression Analysis: The expression of TH in the brains of the 6-OHDA group decreased, while both α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days) pretreatment and treatment significantly improved TH expression. In contrast, the expression of α-synuclein in the brains of the 6-OHDA group increased. α-ALA treatment alleviated this change, but α-ALA pretreatment did not show improvement.

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 14:155:114539.  [Abstract]

    In the open field test, 6-OHDA reduced the movement distance, and both α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days; C57BL/6 mice) pretreatment and α-ALA treatment ameliorated this effect (n = 9–10).

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 14:155:114539.  [Abstract]

    TH expression decreased in the 6-OHDA group, but increased in both the α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days; C57BL/6 mice) + 6-OHDA and 6-OHDA+α-ALA groups.

    α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 14:155:114539.  [Abstract]

    α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days) pretreatment and treatment alleviated the upregulation of S100A9 protein expression induced by 6-OHDA in C57BL/6 mice, as validated by immunofluorescence analysis.

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    • Purity & Documentation

    • References

    • Customer Review

    Description

    α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].

    IC50 & Target

    HIV-1

     

    NF-κB

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA[1]. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    α-Lipoic Acid sodium Related Antibodies
    In Vivo

    C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    228.31

    Formula

    C8H13NaO2S2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(O[Na])CCCCC1SSCC1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature, keep dry and cool

    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    H2O : 35 mg/mL (153.30 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3800 mL 21.9000 mL 43.8001 mL
    5 mM 0.8760 mL 4.3800 mL 8.7600 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (761 KB)

    COA (244 KB) HNMR (246 KB) RP-HPLC (201 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.3800 mL 21.9000 mL 43.8001 mL 109.5002 mL
    5 mM 0.8760 mL 4.3800 mL 8.7600 mL 21.9000 mL
    10 mM 0.4380 mL 2.1900 mL 4.3800 mL 10.9500 mL
    15 mM 0.2920 mL 1.4600 mL 2.9200 mL 7.3000 mL
    20 mM 0.2190 mL 1.0950 mL 2.1900 mL 5.4750 mL
    25 mM 0.1752 mL 0.8760 mL 1.7520 mL 4.3800 mL
    30 mM 0.1460 mL 0.7300 mL 1.4600 mL 3.6500 mL
    40 mM 0.1095 mL 0.5475 mL 1.0950 mL 2.7375 mL
    50 mM 0.0876 mL 0.4380 mL 0.8760 mL 2.1900 mL
    60 mM 0.0730 mL 0.3650 mL 0.7300 mL 1.8250 mL
    80 mM 0.0548 mL 0.2738 mL 0.5475 mL 1.3688 mL
    100 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0950 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    α-Lipoic Acid sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    α-Lipoic Acid2319-84-8Thioctic acid(±)-α-Lipoic acidDL-α-Lipoic acidNF-κBHIVMitochondrial MetabolismEndogenous MetaboliteApoptosisNuclear factor-κBNuclear factor-kappaBHuman immunodeficiency virusantioxidantcofactormitochondrialHIV-1LTRendoplasmicreticulumstressapoptosishepatomaInhibitorinhibitorinhibit

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