β-Glucogallin (Synonyms: Β‐グルコガリン; 1-O-Galloyl-β-D-glucose)

Name: β-Glucogallin
Brand: MedChemExpress
SKU: HY-133708
Rating: 4.5 (1 reviews)

製品番号: HY-133708 純度: 99.82%: Data Sheet SDS COA 取扱説明書
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β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC₅₀ value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research.

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β-Glucogallin 構造式

CAS 番号 : 13405-60-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 168	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 168	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$68	在庫あり	Estimated Time of Arrival: December 31
5 mg	$153	在庫あり	Estimated Time of Arrival: December 31
10 mg	$222	在庫あり	Estimated Time of Arrival: December 31
25 mg	$508	在庫あり	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

顧客検証

•Crop J. 2025 Dec 13.

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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すべてのアイソフォームを表示

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生物活性
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target

IC50: 58 μM (AKR1B1) when using Glyceraldehyde (HY-128748) as AKR1B1 substrate

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	>10 6 Compound: 4	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
A549	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
A549	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	>10 6 Compound: 4	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	>10 6 Compound: 4	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
TE-671	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
TE-671	ED₅₀	>10 6 Compound: 4	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
TE-671	ED₅₀	> 10 6 Compound: 4	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]

体外実験

β-Glucogallin (100 μM; 2 h) can reduce Methylglyoxal-induced oxidative stress in human retinal epithelial cells ARPE-19, decreasing intracellular ROS levels^[1].
β-Glucoside inhibits AKR1B1 with Glyceraldehyde (HY-128748) as substrate, with an IC₅₀ value of 58 μM^[2].
β-Glucogallin (30 μM; 72 h) can inhibit sorbitol accumulation under hyperglycemic conditions in a transgenic mouse lens organ culture model, with an inhibition rate of 73%^[2].
β-Glucogallin can inhibit the activity of AKR1B1 and prevent Sorbitol (HY-B0400) accumulation in RAW264.7 murine macrophage cells, with an inhibition rate of approximately 50%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	ARPE-19 (human retinal epithelial cell line)
Concentration:	100 μM
Incubation Time:	Pre-treated for 2 h
Result:	Decreased the expression levels of AR, αB-crystallin, PDGF, RAGE, and NF-κB.

体内実験

β-Glucogallin (300-1200 mg/kg; p.o.; once daily; 10 days) improves Carbon tetrachloride (HY-Y0298)-induced hepatotoxicity in female Wistar rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Wistar rats (weight 60-80 g), Carbon tetrachloride-induced liver injury model^[4]
Dosage:	300 mg/kg, 600 mg/kg, 1200 mg/kg
Administration:	Oral gavage (p.o.), once daily for 10 days
Result:	Significantly increased the levels of hepatic GSH, SOD, catalase, and GPx. Reduced lipid peroxidation as indicated by the decrease in TBARS levels. Improved the levels of serum transaminases AST and ALT. Reduced central zone necrosis, vacuolation of hepatocytes, and inflammatory cell infiltration.

分子量

332.26

分子式

C₁₃H₁₆O₁₀

CAS 番号

13405-60-2

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)O[C@H](CO)[C@@H](O)[C@@H]1O

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (300.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4.17 mg/mL (12.55 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0097 mL	15.0485 mL	30.0969 mL
5 mM	0.6019 mL	3.0097 mL	6.0194 mL
10 mM	0.3010 mL	1.5048 mL	3.0097 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.82%

Select Batch:

データシート (281 KB) SDS (393 KB)

COA (251 KB) HNMR (228 KB) RP-HPLC (245 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ma Y, Liu F, Xu Y. Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 7;25:9310-9318. [Content Brief]

[2]. Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012;7(4):e31399. [Content Brief]

[3]. Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57(1):71-7. [Content Brief]

[4]. Majeed M, et al. Amelioration of carbon tetrachloride induced hepatotoxicity by Β-glucogallin, a gallic acid derivative of emblica officinalis gaertn.(euphorbiaceae). Science, 2015, 4(7): 696-701.

[5]. Li L, et al. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57(1):71-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.0097 mL	15.0485 mL	30.0969 mL	75.2423 mL
	5 mM	0.6019 mL	3.0097 mL	6.0194 mL	15.0485 mL
	10 mM	0.3010 mL	1.5048 mL	3.0097 mL	7.5242 mL
DMSO	15 mM	0.2006 mL	1.0032 mL	2.0065 mL	5.0162 mL
	20 mM	0.1505 mL	0.7524 mL	1.5048 mL	3.7621 mL
	25 mM	0.1204 mL	0.6019 mL	1.2039 mL	3.0097 mL
	30 mM	0.1003 mL	0.5016 mL	1.0032 mL	2.5081 mL
	40 mM	0.0752 mL	0.3762 mL	0.7524 mL	1.8811 mL
	50 mM	0.0602 mL	0.3010 mL	0.6019 mL	1.5048 mL
	60 mM	0.0502 mL	0.2508 mL	0.5016 mL	1.2540 mL
	80 mM	0.0376 mL	0.1881 mL	0.3762 mL	0.9405 mL
	100 mM	0.0301 mL	0.1505 mL	0.3010 mL	0.7524 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

β-Glucogallin Related Classifications

Neurological Disease Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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β-Glucogallin (Synonyms: Β‐グルコガリン; 1-O-Galloyl-β-D-glucose)

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Complete Stock Solution Preparation Table

β-Glucogallin Related Classifications

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β-Glucogallin (Synonyms: Β‐グルコガリン; 1-O-Galloyl-β-D-glucose)

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純度とドキュメンテーション

参考文献

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β-Glucogallin 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

β-Glucogallin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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