2. Immunology/Inflammation
    Metabolic Enzyme/Protease
  3. COX
    Endogenous Metabolite
  4. γ-Tocopherol

γ-Tocopherol  (Synonyms: D-γ-Tocopherol; (+)-γ-Tocopherol)

Cat. No.: HY-N7148 Purity: ≥98.0%
COA Handling Instructions

γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.

For research use only. We do not sell to patients.

γ-Tocopherol Chemical Structure

γ-Tocopherol Chemical Structure

CAS No. : 54-28-4

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
50 mg USD 330 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of γ-Tocopherol:

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COX COX-1 COX-2 COX-3

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Description

γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1].

IC50 & Target[1]

Cyclooxygenase

 

Human Endogenous Metabolite

 

In Vitro

γ-Tocopherol (D-γ-Tocopherol) is well absorbed and accumulates to a significant degree in some human tissues; it is metabolized, however, largely to 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), which is mainly excreted in the urine[1].
Plasma concentrations of γ-Tocopherol (D-γ-Tocopherol) are inversely associated with the incidence of cardiovascular disease and prostate cancer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

416.68

Appearance

Liquid

Formula

C28H48O2
CAS No.
SMILES

OC1=C(C)C(C)=C2C(CC[[email protected]](CCC[[email protected]](C)CCC[[email protected]](C)CCCC(C)C)(C)O2)=C1
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3999 mL 11.9996 mL 23.9992 mL
5 mM 0.4800 mL 2.3999 mL 4.7998 mL
10 mM 0.2400 mL 1.2000 mL 2.3999 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (6.00 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (241 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

γ-Tocopherol54-28-4D-γ-Tocopherol (+)-γ-TocopherolCOXEndogenous MetaboliteCyclooxygenaseVitaminEantiinflammatoryanti-cancerInhibitorinhibitorinhibit

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