Balsalazide sodium hydrate (Synonyms: Balsalazide disodium dihydrate)

Cat. No.: HY-B0667A Pureza: 98.30%: Ficha de datos
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Balsalazide sodium hydrate is a prodrug of amino salicylic acid that releases mesalamine (HY-15027) in the colon, offering various anti-inflammatory effects in areas of colitis, and it also exerts related anticancer effects by regulating the IL-6/STAT3 pathway.

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Balsalazide sodium hydrate Estructura química

No. CAS : 150399-21-6

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Other Forms of Balsalazide sodium hydrate:

Balsalazide In-stock
Balsalazide disodium Obtener un presupuesto

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Interleukin Related:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Ver todos los productos específicos de isoformas STAT:

Ver todas las isoformas

STAT3 STAT5 STAT6 STAT1

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target^[1]^[2]

IL-6

IL-1

STAT3

In Vivo

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group^[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

437.31

Fòrmula

C₁₇H₁₇N₃Na₂O₈

No. CAS

150399-21-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC(/N=N/C2=CC=C(C(NCCC(O[Na])=O)=O)C=C2)=CC=C1O[Na].O.O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (285.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (228.67 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2867 mL	11.4335 mL	22.8671 mL
5 mM	0.4573 mL	2.2867 mL	4.5734 mL
10 mM	0.2287 mL	1.1434 mL	2.2867 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.30%

Select Batch:

Ficha de datos (272 KB) SDS (254 KB)

COA (247 KB) HNMR (276 KB) LCMS (105 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [Content Brief]

[2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789. [Content Brief]

[3]. Seema A Patil, et al. Balsalazide disodium for the treatment of ulcerative colitis. Expert Rev Gastroenterol Hepatol. 2008 Apr;2(2):177-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.2867 mL	11.4335 mL	22.8671 mL	57.1677 mL
	5 mM	0.4573 mL	2.2867 mL	4.5734 mL	11.4335 mL
	10 mM	0.2287 mL	1.1434 mL	2.2867 mL	5.7168 mL
	15 mM	0.1524 mL	0.7622 mL	1.5245 mL	3.8112 mL
	20 mM	0.1143 mL	0.5717 mL	1.1434 mL	2.8584 mL
	25 mM	0.0915 mL	0.4573 mL	0.9147 mL	2.2867 mL
	30 mM	0.0762 mL	0.3811 mL	0.7622 mL	1.9056 mL
	40 mM	0.0572 mL	0.2858 mL	0.5717 mL	1.4292 mL
	50 mM	0.0457 mL	0.2287 mL	0.4573 mL	1.1434 mL
	60 mM	0.0381 mL	0.1906 mL	0.3811 mL	0.9528 mL
	80 mM	0.0286 mL	0.1429 mL	0.2858 mL	0.7146 mL
	100 mM	0.0229 mL	0.1143 mL	0.2287 mL	0.5717 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Balsalazide sodium hydrate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Balsalazide sodium150399-21-6Balsalazide disodium dihydrateInterleukin RelatedSTATILInhibitorinhibitorinhibit

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