2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt Metabolic Enzyme/Protease
  3. FGFR Wnt Endogenous Metabolite
  4. Heparan Sulfate

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

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CAS 番号 : 9050-30-0

容量 価格（税別） 在庫状況 数量
5 mg $130 在庫あり
10 mg $200 在庫あり
25 mg $390 在庫あり
50 mg $650 在庫あり
100 mg $950 在庫あり
250 mg $1425 在庫あり
500 mg $2065 在庫あり
1 g $2950 在庫あり
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カスタマーレビュー

Based on 20 publication(s) in Google Scholar

Heparan Sulfate 関連抗体

Top Publications Citing Use of Products

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Nov 13:e0234125.  [Abstract]

    Virus load experiment on RSV F protein gene expression treated with andrographolide (12.5 µM; 26.5 h), Heparan Sulfate (HS, 5 mg/mL; 26.5 h), or their combination.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Biomolecules. 2024 Oct 19;14(10):1331.  [Abstract]

    To confirm the interaction of P25 with receptor Heparan Sulfate (HS) on the cell surface, 50 µL P25 or its derivatives at a concentration of 62.5 µg/mL were pre-incubated with 50 µL cell-free HS at different concentrations of 0–0.5 mg/mL at 37 °C for 1 h, mixed with 100 TCID50/50 µL of EV-A71/FY0805, and infected the pre-seeding RD monolayer cells on 96-well plates for 24 h. The CPE was detected and stained using crystal violet. The optical density (OD) at 550 nm was read using the TECAN Infinite 200 PRO instrument.The results showed that HS diminished the infection inhibitions of P25s.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: J Endod. 2024 Aug;50(8):1108-1116.  [Abstract]

    The effect of Heparan Sulfate (HS) on proliferation and endothelial differentiation of DPSCs. Photomicrographs of DPSCs cultured in EM containing different concentrations of Heparan Sulfate (HS, 0.01-100 μg/mL) for up to 5 days. Scale bars: 200 μm.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: J Clin Med. 2023 Oct 10;12(20):6438.

    H&E staining of representative lung tissue in sham, RL, RL + Heparan Sulfate (HS, 7 mg/kg; administered via a perfusion pump) , albu, and albu + HS groups.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jan 8;12(1):134.  [Abstract]

    Calu3 and Caco2 cells were inoculated with Heparan Sulfate (100-500 μg/mL)-pretreated SARS-CoV-2 or SARS-CoV at 0.2 MOI for 2 h at 37 °C. Cell lysates and supernatants were harvested at 24hpi and virus replication was determined with qRT-PCR (n =3).

    Wnt アイソフォーム固有の製品をすべて表示:

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    Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    製品説明

    Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Heparan sulfate is a linear polysaccharide and belongs to the family of glycosaminoglycans. Heparan sulfate is composed of glucuronic acid (GlcA) and iduronic acid (IdoA) residues as well as N-acetyl glucosamines (GlcNAc) with various sulfation modifications, and is typically 50-200 disaccharides in length. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to maintenance of morphogen gradients and co-receptor functions[1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions[2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Heparan Sulfate 関連抗体
    体内実験

    Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning[4]. FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    593.47 (monomer)

    分子式

    C12H19NO20S3 (monomer)
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(OCC1O[C@@H](OC)[C@H](NS(=O)(O)=O)[C@@H](OS(=O)(O)=O)[C@H]1O[C@@H]2OC(C(O)=O)[C@H](O[C@@H]3OC(COS(=O)(O)=O)[C@H](O[C@@H]4OC(C(O)=O)[C@H](OC)[C@H](O)[C@H]4OS(=O)(O)=O)[C@H](O)[C@H]3NS(=O)(O)=O)[C@H](O)[C@H]2O)(O)=O.[n]
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (Need ultrasonic)

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    一般には略語で表示されます：C1V1 = C2V2

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL; Clear solution; Need ultrasonic

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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    純度とドキュメンテーション

    COA (258 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [5]

    Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10 kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline[5].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献
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    Heparan Sulfate Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Heparan9050-30-0FGFRWntEndogenous MetaboliteFibroblast growth factor receptorInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-101916
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