2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt Metabolic Enzyme/Protease
  3. FGFR Wnt Endogenous Metabolite
  4. Heparan Sulfate

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

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CAS No. : 9050-30-0

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Based on 20 publication(s) in Google Scholar

Heparan Sulfate Related Antibodies

Top Publications Citing Use of Products

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Nov 13:e0234125.  [Abstract]

    Virus load experiment on RSV F protein gene expression treated with andrographolide (12.5 µM; 26.5 h), Heparan Sulfate (HS, 5 mg/mL; 26.5 h), or their combination.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Biomolecules. 2024 Oct 19;14(10):1331.  [Abstract]

    To confirm the interaction of P25 with receptor Heparan Sulfate (HS) on the cell surface, 50 µL P25 or its derivatives at a concentration of 62.5 µg/mL were pre-incubated with 50 µL cell-free HS at different concentrations of 0–0.5 mg/mL at 37 °C for 1 h, mixed with 100 TCID50/50 µL of EV-A71/FY0805, and infected the pre-seeding RD monolayer cells on 96-well plates for 24 h. The CPE was detected and stained using crystal violet. The optical density (OD) at 550 nm was read using the TECAN Infinite 200 PRO instrument.The results showed that HS diminished the infection inhibitions of P25s.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: J Endod. 2024 Aug;50(8):1108-1116.  [Abstract]

    The effect of Heparan Sulfate (HS) on proliferation and endothelial differentiation of DPSCs. Photomicrographs of DPSCs cultured in EM containing different concentrations of Heparan Sulfate (HS, 0.01-100 μg/mL) for up to 5 days. Scale bars: 200 μm.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: J Clin Med. 2023 Oct 10;12(20):6438.

    H&E staining of representative lung tissue in sham, RL, RL + Heparan Sulfate (HS, 7 mg/kg; administered via a perfusion pump) , albu, and albu + HS groups.

    Heparan Sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jan 8;12(1):134.  [Abstract]

    Calu3 and Caco2 cells were inoculated with Heparan Sulfate (100-500 μg/mL)-pretreated SARS-CoV-2 or SARS-CoV at 0.2 MOI for 2 h at 37 °C. Cell lysates and supernatants were harvested at 24hpi and virus replication was determined with qRT-PCR (n =3).

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    Description

    Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Heparan sulfate is a linear polysaccharide and belongs to the family of glycosaminoglycans. Heparan sulfate is composed of glucuronic acid (GlcA) and iduronic acid (IdoA) residues as well as N-acetyl glucosamines (GlcNAc) with various sulfation modifications, and is typically 50-200 disaccharides in length. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to maintenance of morphogen gradients and co-receptor functions[1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions[2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Heparan Sulfate Related Antibodies
    In Vivo

    Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning[4]. FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Masse moléculaire

    593.47 (monomer)

    Formule

    C12H19NO20S3 (monomer)
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(OCC1O[C@@H](OC)[C@H](NS(=O)(O)=O)[C@@H](OS(=O)(O)=O)[C@H]1O[C@@H]2OC(C(O)=O)[C@H](O[C@@H]3OC(COS(=O)(O)=O)[C@H](O[C@@H]4OC(C(O)=O)[C@H](OC)[C@H](O)[C@H]4OS(=O)(O)=O)[C@H](O)[C@H]3NS(=O)(O)=O)[C@H](O)[C@H]2O)(O)=O.[n]
    Structure Classification
    Initial Source
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvant et solubilité
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL; Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    SDS (393 KB)

    COA (258 KB)

    Instruction de manipulation (2659 KB)
    Références
    Administration animale
    [5]

    Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10 kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline[5].

    MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
    Références
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    Heparan Sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Heparan9050-30-0FGFRWntEndogenous MetaboliteFibroblast growth factor receptorInhibitorinhibitorinhibit

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