L-Cysteine (Synonyms: Cysteine)

Name: L-Cysteine
Brand: MedChemExpress
SKU: HY-Y0337
Rating: 5.0 (12 reviews)

Cat. No.: HY-Y0337 Purity: 97.0%: Data Sheet
COA

SDS
Handling Instructions
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L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent.

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L-Cysteine 화학구조

CAS No. : 52-90-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	견적 받기
50 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 12 publication(s) in Google Scholar

Other Forms of L-Cysteine:

L-Cysteine-¹³C₃,¹⁵N In-stock
L-Cysteine-¹⁵N In-stock
L-Cysteine-3-¹³C In-stock
L-Cysteine-1-¹³C In-stock
L-Cysteine-¹³C₃ In-stock
L-Cysteine-d₃ In-stock
L-Cysteine-d₂ In-stock
L-Cysteine hydrochloride hydrate In-stock
L-Cysteine hydrochloride In-stock
L-Cysteine (Standard) In-stock
L-Cysteine-¹³C₃,¹⁵N,d₃ 견적 받기
L-Cysteine-d₃,¹⁵N 견적 받기

12 Publications Citing Use of MCE L-Cysteine

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•Related Screening Libraries:

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View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

ERK1

ERK2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	161 μM Compound: 5862	Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells	10.5281/zenodo.7361326
HEK293	EC₅₀	161 μM Compound: 5862	Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells (PubChem AID: 1794812) Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells (PubChem AID: 1794812)	10.5281/zenodo.7361326
HEK293	EC₅₀	376 μM Compound: 5862	Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells	10.5281/zenodo.6782621
HEK293	EC₅₀	376 μM Compound: 5862	Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864) Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)	10.5281/zenodo.6782621
HeLa	IC₅₀	>50 μM Compound: 3a	Cytotoxic activity against HeLa cells Cytotoxic activity against HeLa cells	[PMID: 17524640]
SNB-19	IC₅₀	116 μM Compound: L-cystine	Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting	[PMID: 19932968]

In Vitro

L-Cysteine (0.1-50 μM, 24 and 48 h) increases cell viability of neural stem cells (NSCs) and promotes proliferation and neuronal differentiation of NSCs^[2].
L-cysteine (1 μM, 0-90 min) activates ERK1/2 via CBS/H2S pathway in NSCs^[2].
L-Cysteine (0.1-20 mM, 30 min) results in a decrease in glucose uptake in soleus muscle^[3].
L-Cysteine (0.5 mM, 30 min) increases GLUT3 levels in SH-SY5Y cells and GLUT4 levels in SH-SY5Y cells, soleus muscle and C2C12 muscle cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	NSCs
Concentration:	0.1-50 μM
Incubation Time:	24 and 48 h
Result:	Obviously improved the cell viability of NSCs in a dose-dependent manner at lower doses (0.5, 1, 5 μM) and increased the ratio of BrdU-positive cells against total NSCs at 24 h.

Cell Viability Assay^[2]

Cell Line:	NSCs
Concentration:	1 μM
Incubation Time:	0-90 min
Result:	Induced overexpression of phosphorylated ERK (p-ERK1/2) in NSCs.

In Vivo

L-Cysteine (1-4 mmol/kg, p.o. or i.p., a single dose for 1 h) decreases food intake in rodents, increases respiratory exchange ratio (RER) in mice, increases neuronal activation in the rat brainstem, reduces gastric emptying and suppresses plasma acyl ghrelin levels in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats following an overnight 16-h fast^[1]
Dosage:	1-4 mmol/kg
Administration:	p.o. or i.p., a single dose for 1 h
Result:	Dose-dependently decreased food intake in rats and mice and significantly increased cFLI in the area postrema in rats.

분자량

121.16

화학식

C₃H₇NO₂S

CAS No.

52-90-4

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS)C(O)=O

Structure Classification

Amino acids

Initial Source

Microorganisms

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 5 mg/mL (41.27 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.2535 mL	41.2677 mL	82.5355 mL
5 mM	1.6507 mL	8.2535 mL	16.5071 mL
10 mM	0.8254 mL	4.1268 mL	8.2535 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (825.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: ≥97.0%

Select Batch:

Data Sheet (277 KB) SDS (396 KB)

COA (245 KB) HNMR (208 KB)

Handling Instructions (2659 KB)

References

[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55. [Content Brief]

[2]. Wang Z, et al. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway. Neuroscience. 2013 May 1;237:106-17. [Content Brief]

[3]. Gazit V, et al. L-cysteine increases glucose uptake in mouse soleus muscle and SH-SY5Y cells. Metab Brain Dis. 2003 Sep;18(3):221-31. [Content Brief]

[4]. Takemoto Y. The central effect of L-cysteine on cardiovascular system of the conscious rat. Jpn J Physiol. 1995;45(5):771-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	8.2535 mL	41.2677 mL	82.5355 mL	206.3387 mL
	5 mM	1.6507 mL	8.2535 mL	16.5071 mL	41.2677 mL
	10 mM	0.8254 mL	4.1268 mL	8.2535 mL	20.6339 mL
	15 mM	0.5502 mL	2.7512 mL	5.5024 mL	13.7559 mL
	20 mM	0.4127 mL	2.0634 mL	4.1268 mL	10.3169 mL
	25 mM	0.3301 mL	1.6507 mL	3.3014 mL	8.2535 mL
	30 mM	0.2751 mL	1.3756 mL	2.7512 mL	6.8780 mL
	40 mM	0.2063 mL	1.0317 mL	2.0634 mL	5.1585 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Cysteine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cysteine52-90-4CysteineEnvironmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsconditionallyhydrogensulphideH2SglutathionetaurineghrelinappetiteInhibitorinhibitorinhibit

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L-Cysteine (Synonyms: Cysteine)

고객리뷰

Other Forms of L-Cysteine:

L-Cysteine Related Antibodies

12 Publications Citing Use of MCE L-Cysteine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

L-Cysteine Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

L-Cysteine Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report